1o0l

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[[Image:1o0l.gif|left|200px]]
[[Image:1o0l.gif|left|200px]]
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{{Structure
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|PDB= 1o0l |SIZE=350|CAPTION= <scene name='initialview01'>1o0l</scene>
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The line below this paragraph, containing "STRUCTURE_1o0l", creates the "Structure Box" on the page.
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|SITE=
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|GENE= BCL2L2 OR BCLW OR KIAA0271 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1o0l| PDB=1o0l | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0l OCA], [http://www.ebi.ac.uk/pdbsum/1o0l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o0l RCSB]</span>
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'''THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY'''
'''THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY'''
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[[Category: Lackmann, M.]]
[[Category: Lackmann, M.]]
[[Category: Skea, G L.]]
[[Category: Skea, G L.]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: bcl-2]]
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[[Category: Bcl-2]]
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[[Category: bh3]]
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[[Category: Bh3]]
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[[Category: binding groove]]
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[[Category: Binding groove]]
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[[Category: helical bundle]]
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[[Category: Helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:12:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:38:06 2008''
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Revision as of 00:12, 3 May 2008

Image:1o0l.gif

Template:STRUCTURE 1o0l

THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY


Overview

Pro-survival Bcl-2-related proteins, critical regulators of apoptosis, contain a hydrophobic groove targeted for binding by the BH3 domain of the pro-apoptotic BH3-only proteins. The solution structure of the pro-survival protein Bcl-w, presented here, reveals that the binding groove is not freely accessible as predicted by previous structures of pro-survival Bcl-2-like molecules. Unexpectedly, the groove appears to be occluded by the C-terminal residues. Binding and kinetic data suggest that the C-terminal residues of Bcl-w and Bcl-x(L) modulate pro-survival activity by regulating ligand access to the groove. Binding of the BH3-only proteins, critical for cell death initiation, is likely to displace the hydrophobic C-terminal region of Bcl-w and Bcl-x(L). Moreover, Bcl-w does not act only by sequestering the BH3-only proteins. There fore, pro-survival Bcl-2-like molecules probably control the activation of downstream effectors by a mechanism that remains to be elucidated.

About this Structure

1O0L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity., Hinds MG, Lackmann M, Skea GL, Harrison PJ, Huang DC, Day CL, EMBO J. 2003 Apr 1;22(7):1497-507. PMID:12660157 Page seeded by OCA on Sat May 3 03:12:49 2008

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