1o0d

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[[Image:1o0d.jpg|left|200px]]
[[Image:1o0d.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1o0d |SIZE=350|CAPTION= <scene name='initialview01'>1o0d</scene>, resolution 2.44&Aring;
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The line below this paragraph, containing "STRUCTURE_1o0d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=163:(2-{2-[(5-CARBAMIMIDOYL-1-METHYL-1H-PYRROL-2-YLMETHYL)-CARBAMOYL]-PYRROL-1-YL}-+1-CYCLOHEXYLMETHYL-2-OXO-ETHYLAMINO)-ACETIC+ACID'>163</scene>, <scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SMF:4-SULFOMETHYL-L-PHENYLALANINE'>SMF</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1o0d| PDB=1o0d | SCENE= }}
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|RELATEDENTRY=[[1ppb|1PPB]], [[1a5g|1A5G]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0d OCA], [http://www.ebi.ac.uk/pdbsum/1o0d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o0d RCSB]</span>
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}}
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'''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor'''
'''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor'''
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[[Category: Mack, H.]]
[[Category: Mack, H.]]
[[Category: Seitz, W.]]
[[Category: Seitz, W.]]
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[[Category: ternary complex]]
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[[Category: Ternary complex]]
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[[Category: thrombin/active-site inhibitor/exo-site inhibitor]]
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[[Category: Thrombin/active-site inhibitor/exo-site inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:12:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:38:08 2008''
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Revision as of 00:12, 3 May 2008

Image:1o0d.jpg

Template:STRUCTURE 1o0d

Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor


Contents

Overview

Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1O0D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:12781189 Page seeded by OCA on Sat May 3 03:12:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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