|
|
| Line 1: |
Line 1: |
| - | | + | #REDIRECT [[5yc6]] This PDB entry is obsolete and replaced by 5yc6 |
| - | ==Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6==
| + | |
| - | <StructureSection load='4jni' size='340' side='right' caption='[[4jni]], [[Resolution|resolution]] 1.17Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[4jni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JNI FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PZH:1-(4-BROMOPHENYL)METHANAMINE'>PZH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
| + | |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jnl|4jnl]]</td></tr>
| + | |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jni OCA], [http://pdbe.org/4jni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jni RCSB], [http://www.ebi.ac.uk/pdbsum/4jni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jni ProSAT]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | == Disease ==
| + | |
| - | [[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
| + | |
| - | == Function ==
| + | |
| - | [[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
| + | |
| - | | + | |
| - | ==See Also==
| + | |
| - | *[[Urokinase|Urokinase]]
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Human]]
| + | |
| - | [[Category: U-plasminogen activator]]
| + | |
| - | [[Category: Huang, M]]
| + | |
| - | [[Category: Jiang, L]]
| + | |
| - | [[Category: Yuan, C]]
| + | |
| - | [[Category: Zhang, X]]
| + | |
| - | [[Category: Zhao, B]]
| + | |
| - | [[Category: Halogen]]
| + | |
| - | [[Category: Hydrolase-hydrolase inhibitor complex]]
| + | |
| - | [[Category: Upa]]
| + | |
