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4tw9

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==Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation==
==Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation==
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<StructureSection load='4tw9' size='340' side='right' caption='[[4tw9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4tw9' size='340' side='right'caption='[[4tw9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tw9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TW9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tw9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TW9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=386:N-(2,2-DIFLUORO-5H-[1,3]DIOXOLO[4,5-F]BENZIMIDAZOL-6-YL)-2-{[2-(TRIFLUOROMETHOXY)BENZOYL]AMINO}-1,3-THIAZOLE-4-CARBOXAMIDE'>386</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HSJ:OCTYL+BETA-L-TALOPYRANOSIDE'>HSJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=386:N-(2,2-DIFLUORO-5H-[1,3]DIOXOLO[4,5-F]BENZIMIDAZOL-6-YL)-2-{[2-(TRIFLUOROMETHOXY)BENZOYL]AMINO}-1,3-THIAZOLE-4-CARBOXAMIDE'>386</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HSJ:OCTYL+BETA-L-TALOPYRANOSIDE'>HSJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSNK1D, HCKID ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tw9 OCA], [http://pdbe.org/4tw9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tw9 RCSB], [http://www.ebi.ac.uk/pdbsum/4tw9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tw9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tw9 OCA], [http://pdbe.org/4tw9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tw9 RCSB], [http://www.ebi.ac.uk/pdbsum/4tw9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tw9 ProSAT]</span></td></tr>
</table>
</table>
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==See Also==
==See Also==
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*[[Casein kinase|Casein kinase]]
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*[[Casein kinase 3D structures|Casein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Alscher, V]]
[[Category: Alscher, V]]
[[Category: Berg, S]]
[[Category: Berg, S]]

Revision as of 14:12, 10 May 2019

Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation

PDB ID 4tw9

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