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4aco

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Revision as of 09:38, 6 March 2019

Structure of the budding yeast Ndc10 N-terminal domain

Structural highlights

4aco is a 1 chain structure with sequence from Atcc 18824. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CBF3A_YEAST] Acts as a component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters.

Publication Abstract from PubMed

We have solved the X-ray structure of the amino-terminal half of the yeast kinetochore protein Ndc10 at 1.8 Angstrom resolution. This essential protein is a key constituent of the budding yeast centromere, and is essential for the recruitment of the centromeric nucleosome and establishment of the kinetochore. The fold of the protein shows unexpected similarities to the tyrosine recombinase/lambda-integrase family of proteins, most notably Cre, with some variation in the relative position of the sub-domains. This finding offers new insights into kinetochore evolution and the adaptation of a well-studied protein fold to a novel role. By comparison to tyrosine recombinases, and mutagenesis studies, we have been able to define some of the key DNA-binding motifs.

The structure of the yeast kinetochore Ndc10 DNA-binding domain reveals an unexpected evolutionary relationship to tyrosine recombinases.,Perriches T, Singleton MR J Biol Chem. 2012 Jan 3. PMID:22215672^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Perriches T, Singleton MR. The structure of the yeast kinetochore Ndc10 DNA-binding domain reveals an unexpected evolutionary relationship to tyrosine recombinases. J Biol Chem. 2012 Jan 3. PMID:22215672 doi:10.1074/jbc.C111.318501

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4aco"

Categories: Atcc 18824 | Perriches, T | Singleton, M R | Dna binding protein

@@ Line 1: / Line 1: @@
 ==Structure of the budding yeast Ndc10 N-terminal domain==
-<StructureSection load='4aco' size='340' side='right' caption='[[4aco]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
+<StructureSection load='4aco' size='340' side='right'caption='[[4aco]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[4aco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACO FirstGlance]. <br>

4aco

From Proteopedia

Revision as of 09:38, 6 March 2019

Structure of the budding yeast Ndc10 N-terminal domain

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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