1o7x
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1o7x.jpg|left|200px]] | [[Image:1o7x.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1o7x", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | | | + | --> |
| - | | | + | {{STRUCTURE_1o7x| PDB=1o7x | SCENE= }} |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''CITRATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS''' | '''CITRATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS''' | ||
| Line 23: | Line 20: | ||
==Reference== | ==Reference== | ||
Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile., Bell GS, Russell RJ, Connaris H, Hough DW, Danson MJ, Taylor GL, Eur J Biochem. 2002 Dec;269(24):6250-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12473121 12473121] | Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile., Bell GS, Russell RJ, Connaris H, Hough DW, Danson MJ, Taylor GL, Eur J Biochem. 2002 Dec;269(24):6250-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12473121 12473121] | ||
| - | [[Category: Citrate (Si)-synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sulfolobus solfataricus]] | [[Category: Sulfolobus solfataricus]] | ||
| Line 32: | Line 28: | ||
[[Category: Russell, R J.M.]] | [[Category: Russell, R J.M.]] | ||
[[Category: Taylor, G L.]] | [[Category: Taylor, G L.]] | ||
| - | [[Category: | + | [[Category: Lyase]] |
| - | [[Category: | + | [[Category: Tricarboxylic acid cycle]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:29:58 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:29, 3 May 2008
CITRATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS
Overview
The crystal structure of citrate synthase from the thermophilic Archaeon Sulfolobus solfataricus (optimum growth temperature = 85 degrees C) has been determined, extending the number of crystal structures of citrate synthase from different organisms to a total of five that span the temperature range over which life exists (from psychrophile to hyperthermophile). Detailed structural analysis has revealed possible molecular mechanisms that determine the different stabilities of the five proteins. The key to these mechanisms is the precise structural location of the additional interactions. As one ascends the temperature ladder, the subunit interface of this dimeric enzyme and loop regions are reinforced by complex electrostatic interactions, and there is a reduced exposure of hydrophobic surface. These observations reveal a progressive pattern of stabilization through multiple additional interactions at solvent exposed, loop and interfacial regions.
About this Structure
1O7X is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.
Reference
Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile., Bell GS, Russell RJ, Connaris H, Hough DW, Danson MJ, Taylor GL, Eur J Biochem. 2002 Dec;269(24):6250-60. PMID:12473121 Page seeded by OCA on Sat May 3 03:29:58 2008
