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4mvn

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==Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor==
==Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor==
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<StructureSection load='4mvn' size='340' side='right' caption='[[4mvn]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4mvn' size='340' side='right'caption='[[4mvn]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mvn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mvn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MVN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I1S:[(1S)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-PHENYLETHYL]PHOSPHONIC+ACID'>I1S</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I1S:[(1S)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-PHENYLETHYL]PHOSPHONIC+ACID'>I1S</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ufa|3ufa]], [[3w7s|3w7s]], [[2w7u|2w7u]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvn OCA], [https://pdbe.org/4mvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mvn RCSB], [https://www.ebi.ac.uk/pdbsum/4mvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvn ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPLA, SAOUHSC_01942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93061 STAA8])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvn OCA], [http://pdbe.org/4mvn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mvn RCSB], [http://www.ebi.ac.uk/pdbsum/4mvn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvn ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPLA_STAA8 SPLA_STAA8]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staa8]]
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[[Category: Large Structures]]
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[[Category: Burchacka, E]]
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[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
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[[Category: Dubin, A]]
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[[Category: Burchacka E]]
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[[Category: Dubin, G]]
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[[Category: Dubin A]]
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[[Category: Niemczyk, J S]]
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[[Category: Dubin G]]
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[[Category: Oleksyszyn, J]]
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[[Category: Niemczyk JS]]
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[[Category: Popowicz, G M]]
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[[Category: Oleksyszyn J]]
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[[Category: Potempa, J]]
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[[Category: Popowicz GM]]
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[[Category: Pustelny, K]]
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[[Category: Potempa J]]
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[[Category: Sienczyk, M]]
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[[Category: Pustelny K]]
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[[Category: Wladyka, B]]
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[[Category: Sienczyk M]]
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[[Category: Zdzalik, M]]
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[[Category: Wladyka B]]
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[[Category: Chymotrypsin-like fold]]
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[[Category: Zdzalik M]]
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[[Category: Extracellular staphylococcal protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Serine endopeptidase]]
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Revision as of 10:12, 28 December 2022

Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor

PDB ID 4mvn

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