RNA uridylyltransferase
From Proteopedia
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| - | {{STRUCTURE_3pq1| PDB=3pq1 | SIZE=400| SCENE= |right|CAPTION=Human RNA uridylyltransferase-1, [[3pq1]] }} | ||
| + | <StructureSection load='2q0f' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene=''> | ||
| + | == Function == | ||
'''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]]. | '''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]]. | ||
| + | == Structural highlights == | ||
| + | RNAU-4 active site contains UTP, UMP and Mg+2 ions<ref>PMID:17785418</ref>. | ||
| + | |||
| + | </StructureSection> | ||
== 3D Structures of RNA uridylyltransferase == | == 3D Structures of RNA uridylyltransferase == | ||
Revision as of 08:58, 18 August 2016
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3D Structures of RNA uridylyltransferase
Updated on 18-August-2016
References
- ↑ Stagno J, Aphasizheva I, Rosengarth A, Luecke H, Aphasizhev R. UTP-bound and Apo structures of a minimal RNA uridylyltransferase. J Mol Biol. 2007 Feb 23;366(3):882-99. Epub 2006 Dec 2. PMID:17189640 doi:10.1016/j.jmb.2006.11.065
- ↑ Stagno J, Aphasizheva I, Aphasizhev R, Luecke H. Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14634-9. Epub 2007 Sep 4. PMID:17785418
