1obp

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[[Image:1obp.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1obp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1obp OCA], [http://www.ebi.ac.uk/pdbsum/1obp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1obp RCSB]</span>
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'''ODORANT-BINDING PROTEIN FROM BOVINE NASAL MUCOSA'''
'''ODORANT-BINDING PROTEIN FROM BOVINE NASAL MUCOSA'''
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[[Category: Cambillau, C.]]
[[Category: Cambillau, C.]]
[[Category: Tegoni, M.]]
[[Category: Tegoni, M.]]
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[[Category: lipocalin]]
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[[Category: Lipocalin]]
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[[Category: nose]]
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[[Category: Nose]]
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[[Category: odorant-binding protein]]
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[[Category: Odorant-binding protein]]
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[[Category: olfaction]]
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[[Category: Olfaction]]
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[[Category: transport]]
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[[Category: Transport]]
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Revision as of 00:38, 3 May 2008

Image:1obp.gif

Template:STRUCTURE 1obp

ODORANT-BINDING PROTEIN FROM BOVINE NASAL MUCOSA


Overview

Odorant binding protein (OBP) is the major odorant binding component of mammalian nasal mucosa. The two structures of bovine OBP reported in this paper (one crystallized as purified and one soaked in the presence of a selenium-containing odorant) show that: (i) the OBP dimer is composed of two compact domains related by an approximate two-fold axis of symmetry; (ii) between residues 122 and 123 the polypeptide chains cross from one domain to the other such that each domain is formed by residues from both monomers; (iii) purified OBP already contains two bound odorant molecules (one per monomer)-odorant binding occurs by replacement of these molecules with the added odorant; and (iv) the structure of the odorant binding site can explain OBP's extraordinarily broad odorant specificity.

About this Structure

1OBP is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition., Bianchet MA, Bains G, Pelosi P, Pevsner J, Snyder SH, Monaco HL, Amzel LM, Nat Struct Biol. 1996 Nov;3(11):934-9. PMID:8901871 Page seeded by OCA on Sat May 3 03:38:17 2008

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