This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sequestosome
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
== Structural highlights == | == Structural highlights == | ||
SQS is a multi-domain protein. SQS domain structure includes: <br /> | SQS is a multi-domain protein. SQS domain structure includes: <br /> | ||
| - | PB1 domain which contains Phox and Berm1<br /> | + | *PB1 domain which contains Phox and Berm1<br /> |
| - | ZZ-type zinc finger <br /> | + | *ZZ-type zinc finger <br /> |
| - | SMIR – SOD interaction domain<br /> | + | *SMIR – SOD interaction domain<br /> |
| - | TB – TRAF6 binding motif<br /> | + | *TB – TRAF6 binding motif<br /> |
| - | LC3 – microtubule-associated protein 1 light chain 3B<br /> | + | *LC3 – microtubule-associated protein 1 light chain 3B<br /> |
| - | LIR – interaction region<br /> | + | *LIR – interaction region<br /> |
| - | UBA – ubiquitin association domain. | + | *UBA – ubiquitin association domain. |
== Relevance == | == Relevance == | ||
| Line 21: | Line 21: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[1q02]], [[2jy7]], [[2jy8]], [[2k0b]], [[2knv]] – | + | [[1q02]], [[2jy7]], [[2jy8]], [[2k0b]], [[2knv]] – hSQS UBA domain – human - NMR<br /> |
[[3b0f]] – mSQS UBA domain – mouse <br /> | [[3b0f]] – mSQS UBA domain – mouse <br /> | ||
[[2rru]] – mSQS UBA domain - NMR<br /> | [[2rru]] – mSQS UBA domain - NMR<br /> | ||
| Line 28: | Line 28: | ||
[[3ade]] – mSQS + KEAP-1 – mouse<br /> | [[3ade]] – mSQS + KEAP-1 – mouse<br /> | ||
[[4mjs]] – hSQS-1 PB1 domain + protein kinase C zeta type<br /> | [[4mjs]] – hSQS-1 PB1 domain + protein kinase C zeta type<br /> | ||
| - | [[4uf8]], [[4uf9]] – hSQS-1 PB1 | + | [[4uf8]], [[4uf9]] – hSQS-1 PB1 domain – Cryo EM<br /> |
| + | [[5yp7]], [[5yp8]], [[5ypa]], [[5ypb]], [[5ypc]], [[5ype]], [[5ypg]], [[5yph]], [[5ypi]] – hSQS-1 residues 126-180<br /> | ||
Revision as of 20:30, 17 September 2018
| |||||||||||
References
- ↑ Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol. 2004 Sep;24(18):8055-68. PMID:15340068 doi:10.1128/MCB.24.18.8055-8068.2004
- ↑ Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2012 Jan;96(1):87-95. doi: 10.1016/j.pneurobio.2011.11.005. Epub , 2011 Nov 22. PMID:22138392 doi:http://dx.doi.org/10.1016/j.pneurobio.2011.11.005
