Stimulator of interferon genes
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
| - | The cyclic dinucleotide binds the STING in a U-shaped cleft between the 2 monomers<ref>PMID:23910378</ref>. | + | The <scene name='57/573101/Cv/3'>cyclic dinucleotide binds the STING in a U-shaped cleft between the 2 monomers</scene><ref>PMID:23910378</ref>. Water molecules shown as red spheres. |
</StructureSection> | </StructureSection> | ||
Revision as of 11:46, 1 September 2016
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3D structures of STING
(Updated on 01-September-2016
References
- ↑ Poltorak A, Kurmyshkina O, Volkova T. Stimulator of interferon genes (STING): A "new chapter" in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity. Cytokine Growth Factor Rev. 2016 Jun;29:83-91. doi:, 10.1016/j.cytogfr.2016.02.009. Epub 2016 Mar 4. PMID:26980676 doi:http://dx.doi.org/10.1016/j.cytogfr.2016.02.009
- ↑ Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell. 2013 Aug 15;154(4):748-62. doi: 10.1016/j.cell.2013.07.023. Epub 2013 Aug, 1. PMID:23910378 doi:10.1016/j.cell.2013.07.023
