Sulfurtransferase
From Proteopedia
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| - | {{STRUCTURE_1yt8| PDB=1yt8 | SIZE=400| SCENE= |right|CAPTION=SeMet thiosulfate sulfurtransferase complex with glycerol and sulfite, [[1yt8]] }} | ||
| + | <StructureSection load='4jgt' size='350' side='right' caption='Human mercaptopyruvate sulfurtransferase with mercaptocysteine complex with pyruvate, sulfate and glycerol (PDB entry [[4jgt]])' scene=''> | ||
| + | == Function == | ||
'''Sulfurtransferase''' (ST) are enzymes which transfer sulfur-containing groups<ref>PMID:20135153</ref>. | '''Sulfurtransferase''' (ST) are enzymes which transfer sulfur-containing groups<ref>PMID:20135153</ref>. | ||
*'''Thiosulfate ST''' (TST) catalyzes the conversion of thiosulfate and cyanide to sulfite and thiocyanate<ref>PMID:27270587</ref>.<br /> | *'''Thiosulfate ST''' (TST) catalyzes the conversion of thiosulfate and cyanide to sulfite and thiocyanate<ref>PMID:27270587</ref>.<br /> | ||
*'''Mercaptopyruvate ST''' (MST) transfers sulfate from mercaptopyruvate<ref>PMID:10951223</ref>.<br /> | *'''Mercaptopyruvate ST''' (MST) transfers sulfate from mercaptopyruvate<ref>PMID:10951223</ref>.<br /> | ||
| + | |||
| + | == Structural highlights == | ||
| + | The active site of MST contains mercaptocysteine and pyruvate<ref>PMID:23698001</ref>. | ||
| + | </StructureSection> | ||
== 3D Structures of sulfurtransferase == | == 3D Structures of sulfurtransferase == | ||
Revision as of 08:24, 5 September 2016
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3D Structures of sulfurtransferase
Updated on 05-September-2016
References
- ↑ Papenbrock J, Guretzki S, Henne M. Latest news about the sulfurtransferase protein family of higher plants. Amino Acids. 2011 Jun;41(1):43-57. doi: 10.1007/s00726-010-0478-6. Epub 2010 Feb , 5. PMID:20135153 doi:http://dx.doi.org/10.1007/s00726-010-0478-6
- ↑ Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipila P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. PMID:27270587 doi:http://dx.doi.org/10.1038/nm.4115
- ↑ Nakamura T, Yamaguchi Y, Sano H. Plant mercaptopyruvate sulfurtransferases: molecular cloning, subcellular localization and enzymatic activities. Eur J Biochem. 2000 Sep;267(17):5621-30. PMID:10951223
- ↑ Yadav PK, Yamada K, Chiku T, Koutmos M, Banerjee R. Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase. J Biol Chem. 2013 May 22. PMID:23698001 doi:10.1074/jbc.M113.466177
