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Symplekin

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<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A C terminal phosphatase (green) and phosphate ion (PDB code [[3o2s]])' scene=''>
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<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A phosphatase C terminal (green) and phosphate ion (PDB code [[3o2s]])' scene=''>
== Function ==
== Function ==
'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72)<ref>PMID:8769423</ref>.
'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72)<ref>PMID:8769423</ref>.

Revision as of 08:00, 6 September 2016

Human symplekin N terminal (grey) complex with RNA polymerase II subunit A phosphatase C terminal (green) and phosphate ion (PDB code 3o2s)

Drag the structure with the mouse to rotate

3D Structures of symplekin

Updated on 06-September-2016

3gs3 – DmSMPK N terminal – Drosophila melanogaster
3o2t, 3odr – hSMPK N terminal – human
3ods – hSMPK N terminal (mutant)
3o2s – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase
4h3h, 3o2q, 4h3k – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide
4imi, 4imj – DmSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide

References

  1. ↑ Keon BH, Schafer S, Kuhn C, Grund C, Franke WW. Symplekin, a novel type of tight junction plaque protein. J Cell Biol. 1996 Aug;134(4):1003-18. PMID:8769423
  2. ↑ . PMID:216315890657

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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