TATA-Binding Protein
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load='1tgh' size=' | + | <StructureSection load='1tgh' size='450' side='right' scene='' caption='Human TATA-binding protein complex with DNA TATA box (PDB code [[1tgh]])'> |
== Function == | == Function == | ||
[[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>. Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also<br /> | [[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>. Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also<br /> | ||
| Line 22: | Line 22: | ||
<scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>. | <scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>. | ||
| - | The interactions of TBP with the DNA TATA box occurs with the minor groove of the DNA. The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic<ref>PMID:8757291</ref>. | + | The interactions of <scene name='10/100866/Cv/2'>TBP with the DNA TATA box occurs with the minor groove of the DNA</scene>. The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic<ref>PMID:8757291</ref>. |
{{Clear}} | {{Clear}} | ||
Revision as of 07:32, 8 September 2016
| |||||||||||
3D Structures of TATA-binding protein
Updated on 08-September-2016
References
- ↑ Caporaso N. Genetic susceptibility in the occupational setting: introduction to the workshop. Med Lav. 1995 May-Jun;86(3):199-206. PMID:7565278
- ↑ van Roon-Mom WM, Reid SJ, Faull RL, Snell RG. TATA-binding protein in neurodegenerative disease. Neuroscience. 2005;133(4):863-72. PMID:15916858 doi:http://dx.doi.org/10.1016/j.neuroscience.2005.03.024
- ↑ Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE. How proteins recognize the TATA box. J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291 doi:10.1006/jmbi.1996.0456
Proteopedia Page Contributors and Editors (what is this?)
Ala Jelani, Michal Harel, Eran Hodis, Alexander Berchansky, David Canner
