1od1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1od1.jpg|left|200px]]
[[Image:1od1.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1od1 |SIZE=350|CAPTION= <scene name='initialview01'>1od1</scene>, resolution 1.37&Aring;
+
The line below this paragraph, containing "STRUCTURE_1od1", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=CAT:Catalytic+Aspartates'>CAT</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CHF:CYCLOHEXYLFLUOROSTATONE'>CHF</scene>, <scene name='pdbligand=DPH:DEAMINO-METHYL-PHENYLALANINE'>DPH</scene>, <scene name='pdbligand=EMR:N-AMINOETHYLMORPHOLINE'>EMR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TSM:2-HYDROSULFONYL-2-METHYLPROPANE'>TSM</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1od1| PDB=1od1 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1od1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od1 OCA], [http://www.ebi.ac.uk/pdbsum/1od1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1od1 RCSB]</span>
+
-
}}
+
'''ENDOTHIAPEPSIN PD135,040 COMPLEX'''
'''ENDOTHIAPEPSIN PD135,040 COMPLEX'''
Line 32: Line 29:
[[Category: Mall, S.]]
[[Category: Mall, S.]]
[[Category: Wood, S P.]]
[[Category: Wood, S P.]]
-
[[Category: hydrolase,acid proteinase,inhibitor,aspartyl protease]]
+
[[Category: Hydrolase,acid proteinase,inhibitor,aspartyl protease]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:41:12 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:43:27 2008''
+

Revision as of 00:41, 3 May 2008

Image:1od1.jpg

Template:STRUCTURE 1od1

ENDOTHIAPEPSIN PD135,040 COMPLEX


Overview

The crystal structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 has been anisotropically refined to a resolution of 1.37 A. The structure of this inhibitor complex is in agreement with previous structures of endothiapepsin gem-diol inhibitor complexes that have been used to develop proposed catalytic mechanisms. However, the increase in resolution over previous structures confirms the presence of a number of short hydrogen bonds within the active site that are likely to play an important role in the catalytic mechanism. The presence of low-barrier hydrogen bonds was indicated in a previous one-dimensional H NMR spectrum.

About this Structure

1OD1 is a Protein complex structure of sequences from Cryphonectria parasitica. Full crystallographic information is available from OCA.

Reference

The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A., Coates L, Erskine PT, Mall S, Williams PA, Gill RS, Wood SP, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):978-81. Epub 2003, May 23. PMID:12777758 Page seeded by OCA on Sat May 3 03:41:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1od1"
Personal tools