5gox

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'''Unreleased structure'''
 
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The entry 5gox is ON HOLD until Paper Publication
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==Eukaryotic Rad50 Functions as A Rod-shaped Dimer==
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<StructureSection load='5gox' size='340' side='right' caption='[[5gox]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5gox]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GOX FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gox OCA], [http://pdbe.org/5gox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gox RCSB], [http://www.ebi.ac.uk/pdbsum/5gox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gox ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/RAD50_HUMAN RAD50_HUMAN]] Nijmegen breakage syndrome-like disorder;Hereditary breast and ovarian cancer syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/RAD50_HUMAN RAD50_HUMAN]] Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).<ref>PMID:10888888</ref> <ref>PMID:11741547</ref> <ref>PMID:15064416</ref> <ref>PMID:9590181</ref> <ref>PMID:9651580</ref> <ref>PMID:9705271</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cho, Y]]
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[[Category: Hohl, M]]
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[[Category: Jeong, E]]
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[[Category: Jin, K S]]
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[[Category: Krezel, A]]
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[[Category: Padjasek, M]]
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[[Category: Park, Y B]]
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[[Category: Petrini, J H.J]]
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[[Category: Dna repair]]
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[[Category: Hydrolase]]

Revision as of 18:03, 1 February 2017

Eukaryotic Rad50 Functions as A Rod-shaped Dimer

5gox, resolution 2.41Å

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