5grj

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m (Protected "5grj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5grj is ON HOLD
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==Crystal structure of human PD-L1 with monoclonal antibody avelumab==
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<StructureSection load='5grj' size='340' side='right' caption='[[5grj]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
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Authors: Liu, K., Tan, S., Chai, Y., Chen, D., Song, H., Zhang, C.W.-H., Shi, Y., Liu, J., Tan, W., Lyu, J., Gao, S., Yan, J., Qi, J., Gao, G.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5grj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GRJ FirstGlance]. <br>
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Description: Crystal structure of human PD-L1 with monoclonal antibody avelumab
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5grj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5grj OCA], [http://pdbe.org/5grj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5grj RCSB], [http://www.ebi.ac.uk/pdbsum/5grj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5grj ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chai, Y]]
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[[Category: Chen, D]]
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[[Category: Gao, G F]]
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[[Category: Gao, S]]
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[[Category: Liu, J]]
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[[Category: Liu, K]]
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[[Category: Lyu, J]]
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[[Category: Qi, J]]
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[[Category: Shi, Y]]
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[[Category: Song, H]]
[[Category: Tan, S]]
[[Category: Tan, S]]
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[[Category: Gao, G.F]]
 
[[Category: Tan, W]]
[[Category: Tan, W]]
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[[Category: Liu, J]]
 
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[[Category: Song, H]]
 
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[[Category: Shi, Y]]
 
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[[Category: Gao, S]]
 
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[[Category: Lyu, J]]
 
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[[Category: Chai, Y]]
 
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[[Category: Liu, K]]
 
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[[Category: Chen, D]]
 
[[Category: Yan, J]]
[[Category: Yan, J]]
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[[Category: Zhang, C.W.-H]]
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[[Category: Zhang, C W.H]]
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[[Category: Qi, J]]
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[[Category: Avelumab]]
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[[Category: Immune system]]
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[[Category: Monoclonal antibody]]
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[[Category: Pd-l1]]
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[[Category: Tumor immunothepapy]]

Revision as of 18:18, 2 November 2016

Crystal structure of human PD-L1 with monoclonal antibody avelumab

5grj, resolution 3.21Å

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