1oh4

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[[Image:1oh4.jpg|left|200px]]
[[Image:1oh4.jpg|left|200px]]
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{{Structure
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|PDB= 1oh4 |SIZE=350|CAPTION= <scene name='initialview01'>1oh4</scene>, resolution 1.35&Aring;
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The line below this paragraph, containing "STRUCTURE_1oh4", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1oh4| PDB=1oh4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oh4 OCA], [http://www.ebi.ac.uk/pdbsum/1oh4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oh4 RCSB]</span>
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}}
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'''STRUCTURAL AND THERMODYNAMIC DISSECTION OF SPECIFIC MANNAN RECOGNITION BY A CARBOHYDRATE-BINDING MODULE'''
'''STRUCTURAL AND THERMODYNAMIC DISSECTION OF SPECIFIC MANNAN RECOGNITION BY A CARBOHYDRATE-BINDING MODULE'''
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[[Category: Nurizzo, D.]]
[[Category: Nurizzo, D.]]
[[Category: Revett, T J.]]
[[Category: Revett, T J.]]
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[[Category: carbohydrate binding module]]
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[[Category: Carbohydrate binding module]]
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[[Category: glycoside hydrolase]]
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[[Category: Glycoside hydrolase]]
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[[Category: lectin]]
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[[Category: Lectin]]
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[[Category: mannan]]
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[[Category: Mannan]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:50:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:45:14 2008''
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Revision as of 00:50, 3 May 2008

Image:1oh4.jpg

Template:STRUCTURE 1oh4

STRUCTURAL AND THERMODYNAMIC DISSECTION OF SPECIFIC MANNAN RECOGNITION BY A CARBOHYDRATE-BINDING MODULE


Overview

The C-terminal 176 amino acids of a Thermotoga maritima mannanase (Man5) constitute a carbohydrate binding module (CBM) that has been classified into CBM family 27. The isolated CBM27 domain, named TmCBM27, binds tightly (K(a)s 10(5)-10(6) M(-1)) to beta-1, 4-mannooligosaccharides, carob galactomannan, and konjac glucomannan, but not to cellulose (insoluble and soluble) or soluble birchwood xylan. The X-ray crystal structures of native TmCBM27, a TmCBM27-mannohexaose complex, and a TmCBM27-6(3),6(4)-alpha-D-galactosyl-mannopentaose complex at 2.0 A, 1.6 A, and 1.35 A, respectively, reveal the basis of TmCBM27's specificity for mannans. In particular, the latter complex, which is the first structure of a CBM in complex with a branched plant cell wall polysaccharide, illustrates how the architecture of the binding site can influence the recognition of naturally substituted polysaccharides.

About this Structure

1OH4 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structural and thermodynamic dissection of specific mannan recognition by a carbohydrate binding module, TmCBM27., Boraston AB, Revett TJ, Boraston CM, Nurizzo D, Davies GJ, Structure. 2003 Jun;11(6):665-75. PMID:12791255 Page seeded by OCA on Sat May 3 03:50:26 2008

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