5lof

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m (Protected "5lof" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5lof is ON HOLD
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==Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1==
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<StructureSection load='5lof' size='340' side='right' caption='[[5lof]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Dokurno, P., Kotschy, A., Szlavik, Z., Murray, J., Davidson, J., Csekei, M., Paczal, A., Szabo, Z., Sipos, S., Radics, G., Proszenyak, A., Balint, B., Ondi, L., Blasko, G., Robertson, A., Surgenor, A., Chen, I., Matassova, N., Smith, J., Pedder, C., Graham, C., Geneste, O.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lof]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOF FirstGlance]. <br>
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Description: Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=70R:(2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic+acid'>70R</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lof OCA], [http://pdbe.org/5lof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lof RCSB], [http://www.ebi.ac.uk/pdbsum/5lof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lof ProSAT]</span></td></tr>
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[[Category: Paczal, A]]
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</table>
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[[Category: Pedder, C]]
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== Function ==
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[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
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__TOC__
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</StructureSection>
[[Category: Balint, B]]
[[Category: Balint, B]]
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[[Category: Sipos, S]]
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[[Category: Blasko, G]]
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[[Category: Chen, I]]
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[[Category: Csekei, M]]
[[Category: Davidson, J]]
[[Category: Davidson, J]]
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[[Category: Szabo, Z]]
 
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[[Category: Blasko, G]]
 
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[[Category: Szlavik, Z]]
 
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[[Category: Proszenyak, A]]
 
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[[Category: Murray, J]]
 
[[Category: Dokurno, P]]
[[Category: Dokurno, P]]
[[Category: Geneste, O]]
[[Category: Geneste, O]]
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[[Category: Csekei, M]]
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[[Category: Graham, C]]
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[[Category: Surgenor, A]]
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[[Category: Kotschy, A]]
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[[Category: Chen, I]]
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[[Category: Matassova, N]]
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[[Category: Murray, J]]
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[[Category: Ondi, L]]
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[[Category: Paczal, A]]
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[[Category: Pedder, C]]
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[[Category: Proszenyak, A]]
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[[Category: Radics, G]]
[[Category: Robertson, A]]
[[Category: Robertson, A]]
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[[Category: Sipos, S]]
[[Category: Smith, J]]
[[Category: Smith, J]]
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[[Category: Ondi, L]]
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[[Category: Surgenor, A]]
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[[Category: Matassova, N]]
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[[Category: Szabo, Z]]
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[[Category: Radics, G]]
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[[Category: Szlavik, Z]]
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[[Category: Kotschy, A]]
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[[Category: Apoptosis-inhibitor complex]]
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[[Category: Graham, C]]
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[[Category: Mbp]]
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[[Category: Mcl-1]]
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[[Category: S s63845]]

Revision as of 18:48, 26 October 2016

Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1

5lof, resolution 2.20Å

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