1ohu

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[[Image:1ohu.jpg|left|200px]]
[[Image:1ohu.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ohu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ohu OCA], [http://www.ebi.ac.uk/pdbsum/1ohu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ohu RCSB]</span>
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'''STRUCTURE OF CAENORHABDITIS ELEGANS CED-9'''
'''STRUCTURE OF CAENORHABDITIS ELEGANS CED-9'''
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[[Category: Jeong, J S.]]
[[Category: Jeong, J S.]]
[[Category: Oh, B H.]]
[[Category: Oh, B H.]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: bcl-2 family]]
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[[Category: Bcl-2 family]]
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[[Category: ced-9]]
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[[Category: Ced-9]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:52:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:45:37 2008''
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Revision as of 00:52, 3 May 2008

Image:1ohu.jpg

Template:STRUCTURE 1ohu

STRUCTURE OF CAENORHABDITIS ELEGANS CED-9


Overview

The interactions between B-cell lymphoma 2 (BCL-2) family members are known to be mediated through the binding of the BH3 domain of a proapoptotic member to the BH3-binding groove of an antiapoptotic member. We determined the crystal structure of antiapoptotic CED-9, which reveals a unique C-terminal helix altering the common BH3-binding region. A coexpression system to produce CED-9 in complex with proapoptotic EGL-1 enabled us to show that the binding of EGL-1 to CED-9 is extremely stable, raising the melting temperature (T(M)) of CED-9 by 25 degrees C, and that the binding surface of CED-9 extends beyond the BH3-binding region and reaches the BH4 domain. Consistently, the T(M) and a 1H-15N correlation NMR spectrum of CED-9 in complex with EGL-1 are drastically different from those of CED-9 in complex with the EGL-1 BH3 peptide. The data suggest that the recognition between other BCL-2 family members may also involve much wider protein surfaces than is previously thought.

About this Structure

1OHU is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions., Woo JS, Jung JS, Ha NC, Shin J, Kim KH, Lee W, Oh BH, Cell Death Differ. 2003 Dec;10(12):1310-9. PMID:12894216 Page seeded by OCA on Sat May 3 03:52:00 2008

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