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5lqr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-5-(6-ethylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide== | |
| - | + | <StructureSection load='5lqr' size='340' side='right' caption='[[5lqr]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lqr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LQR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=72W:~{N}-[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-ETHYLPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-BIS(OXIDANYL)BENZAMIDE'>72W</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqr OCA], [http://pdbe.org/5lqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lqr RCSB], [http://www.ebi.ac.uk/pdbsum/5lqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Catechol O-methyltransferase]] | ||
[[Category: Ehler, A]] | [[Category: Ehler, A]] | ||
| - | [[Category: Rudolph, M.G]] | ||
[[Category: Lerner, C]] | [[Category: Lerner, C]] | ||
| + | [[Category: Rudolph, M G]] | ||
| + | [[Category: Methyltransferase]] | ||
| + | [[Category: Neurotransmitter degradation]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 21:43, 5 October 2016
Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-5-(6-ethylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide
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