5lrm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of di-zinc MCR-1 in P41212 space group== | |
| - | + | <StructureSection load='5lrm' size='340' side='right' caption='[[5lrm]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lrm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LRM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lrm OCA], [http://pdbe.org/5lrm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lrm RCSB], [http://www.ebi.ac.uk/pdbsum/5lrm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lrm ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MCR1_ECOLX MCR1_ECOLX]] Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).<ref>PMID:26603172</ref> Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).<ref>PMID:26603172</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hinchliffe, P]] | ||
[[Category: Spencer, J]] | [[Category: Spencer, J]] | ||
| - | [[Category: | + | [[Category: Colistin]] |
| + | [[Category: Metalloenzyme]] | ||
| + | [[Category: Phosphoethanolamine]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Zinc]] | ||
Revision as of 02:16, 11 December 2016
Structure of di-zinc MCR-1 in P41212 space group
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