1oit

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[[Image:1oit.jpg|left|200px]]
[[Image:1oit.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1oit |SIZE=350|CAPTION= <scene name='initialview01'>1oit</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1oit", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Hdt+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HDT:4-[(4-IMIDAZO[1,2-A]PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]BENZENESULFONAMIDE'>HDT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1oit| PDB=1oit | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oit OCA], [http://www.ebi.ac.uk/pdbsum/1oit PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oit RCSB]</span>
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}}
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'''IMIDAZOPYRIDINES: A POTENT AND SELECTIVE CLASS OF CYCLIN-DEPENDENT KINASE INHIBITORS IDENTIFIED THROUGH STRUCTURE-BASED HYBRIDISATION'''
'''IMIDAZOPYRIDINES: A POTENT AND SELECTIVE CLASS OF CYCLIN-DEPENDENT KINASE INHIBITORS IDENTIFIED THROUGH STRUCTURE-BASED HYBRIDISATION'''
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[[Category: Pauptit, R A.]]
[[Category: Pauptit, R A.]]
[[Category: Thomas, A P.]]
[[Category: Thomas, A P.]]
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[[Category: protein kinase]]
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[[Category: Protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:54:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:45:58 2008''
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Revision as of 00:54, 3 May 2008

Image:1oit.jpg

Template:STRUCTURE 1oit

IMIDAZOPYRIDINES: A POTENT AND SELECTIVE CLASS OF CYCLIN-DEPENDENT KINASE INHIBITORS IDENTIFIED THROUGH STRUCTURE-BASED HYBRIDISATION


Overview

High-throughput screening identified the imidazo[1,2-a]pyridine and bisanilinopyrimidine series as inhibitors of the cyclin-dependent kinase CDK4. Comparison of their experimentally-determined binding modes and emerging structure-activity trends led to the development of potent and selective imidazo[1,2-a]pyridine inhibitors for CDK4 and in particular CDK2.

About this Structure

1OIT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation., Anderson M, Beattie JF, Breault GA, Breed J, Byth KF, Culshaw JD, Ellston RP, Green S, Minshull CA, Norman RA, Pauptit RA, Stanway J, Thomas AP, Jewsbury PJ, Bioorg Med Chem Lett. 2003 Sep 15;13(18):3021-6. PMID:12941325 Page seeded by OCA on Sat May 3 03:54:12 2008

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OCA

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