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5t3d
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of holo-EntF a nonribosomal peptide synthetase in the thioester-forming conformation== | |
| - | + | <StructureSection load='5t3d' size='340' side='right' caption='[[5t3d]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t3d]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zxj 4zxj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T3D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=75C:5-({[(2R,3S)-3-AMINO-4-HYDROXY-2-{[2-({N-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}BUTYL]SULFONYL}AMINO)-5-DEOXYADENOSINE'>75C</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3d OCA], [http://pdbe.org/5t3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t3d RCSB], [http://www.ebi.ac.uk/pdbsum/5t3d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3d ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Sundlov, J | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/ENTF_ECOLI ENTF_ECOLI]] Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE). |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Drake, E J]] | ||
| + | [[Category: Gulick, A M]] | ||
| + | [[Category: Miller, B R]] | ||
| + | [[Category: Sundlov, J A]] | ||
| + | [[Category: Adenylation]] | ||
| + | [[Category: Biosynthetic protein]] | ||
| + | [[Category: Condensation]] | ||
| + | [[Category: Nonribosomal peptide synthetase]] | ||
| + | [[Category: Nrp]] | ||
| + | [[Category: Pcp]] | ||
| + | [[Category: Phosphopantetheine]] | ||
| + | [[Category: Thioesterase]] | ||
Revision as of 13:32, 21 September 2016
Crystal structure of holo-EntF a nonribosomal peptide synthetase in the thioester-forming conformation
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