1olz

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[[Image:1olz.jpg|left|200px]]
[[Image:1olz.jpg|left|200px]]
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{{Structure
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|PDB= 1olz |SIZE=350|CAPTION= <scene name='initialview01'>1olz</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1olz", creates the "Structure Box" on the page.
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01437 PSI], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00409 IG], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01403 Sema]</span>
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{{STRUCTURE_1olz| PDB=1olz | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1olz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1olz OCA], [http://www.ebi.ac.uk/pdbsum/1olz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1olz RCSB]</span>
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'''THE LIGAND-BINDING FACE OF THE SEMAPHORINS REVEALED BY THE HIGH RESOLUTION CRYSTAL STRUCTURE OF SEMA4D'''
'''THE LIGAND-BINDING FACE OF THE SEMAPHORINS REVEALED BY THE HIGH RESOLUTION CRYSTAL STRUCTURE OF SEMA4D'''
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[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
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[[Category: beta-propeller]]
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[[Category: Beta-propeller]]
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[[Category: cd100]]
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[[Category: Cd100]]
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[[Category: extracellular receptor]]
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[[Category: Extracellular receptor]]
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[[Category: glycoprotein developmental protein]]
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[[Category: Glycoprotein developmental protein]]
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[[Category: ig-like domain]]
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[[Category: Ig-like domain]]
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[[Category: neurogenesis]]
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[[Category: Neurogenesis]]
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[[Category: psi domain]]
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[[Category: Psi domain]]
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[[Category: semaphorin]]
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[[Category: Semaphorin]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:08:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:47:07 2008''
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Revision as of 05:08, 13 April 2008

Image:1olz.jpg

Template:STRUCTURE 1olz

THE LIGAND-BINDING FACE OF THE SEMAPHORINS REVEALED BY THE HIGH RESOLUTION CRYSTAL STRUCTURE OF SEMA4D


Overview

Semaphorins, proteins characterized by an extracellular sema domain, regulate axon guidance, immune function and angiogenesis. The crystal structure of SEMA4D (residues 1-657) shows the sema topology to be a seven-bladed beta-propeller, revealing an unexpected homology with integrins. The sema beta-propeller contains a distinctive 77-residue insertion between beta-strands C and D of blade 5. Blade 7 is followed by a domain common to plexins, semaphorins and integrins (PSI domain), which forms a compact cysteine knot abutting the side of the propeller, and an Ig-like domain. The top face of the beta-propeller presents prominent loops characteristic of semaphorins. In addition to limited contact between the Ig-like domains, the homodimer is stabilized through extensive interactions between the top faces in a sector of the beta-propeller used for heterodimerization in integrins. This face of the propeller also mediates ligand binding in integrins, and functional data for semaphorin-receptor interactions map to the equivalent surface.

About this Structure

1OLZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D., Love CA, Harlos K, Mavaddat N, Davis SJ, Stuart DI, Jones EY, Esnouf RM, Nat Struct Biol. 2003 Oct;10(10):843-8. Epub 2003 Sep 7. PMID:12958590 Page seeded by OCA on Sun Apr 13 08:08:23 2008

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