5t5g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==human SETD8 in complex with MS2177== | |
| - | + | <StructureSection load='5t5g' size='340' side='right' caption='[[5t5g]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t5g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T5G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=75P:7-(2-AMINOETHOXY)-6-METHOXY-2-(PYRROLIDIN-1-YL)-N-[5-(PYRROLIDIN-1-YL)PENTYL]QUINAZOLIN-4-AMINE'>75P</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5g OCA], [http://pdbe.org/5t5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t5g RCSB], [http://www.ebi.ac.uk/pdbsum/5t5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5g ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KMT5A_HUMAN KMT5A_HUMAN]] Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.<ref>PMID:12086618</ref> <ref>PMID:12121615</ref> <ref>PMID:15200950</ref> <ref>PMID:15933069</ref> <ref>PMID:15933070</ref> <ref>PMID:16517599</ref> <ref>PMID:17707234</ref> <ref>PMID:23478445</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Babault, N]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Brown, P J]] | ||
| + | [[Category: Butler, K V]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Jin, J]] | ||
| + | [[Category: Ma, A]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Tempel, W]] | ||
| + | [[Category: Yu, W]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 17:13, 3 October 2016
human SETD8 in complex with MS2177
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