1oms

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[[Image:1oms.gif|left|200px]]
[[Image:1oms.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1oms |SIZE=350|CAPTION= <scene name='initialview01'>1oms</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1oms", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO2:SULFUR+DIOXIDE'>SO2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= tig ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1oms| PDB=1oms | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oms OCA], [http://www.ebi.ac.uk/pdbsum/1oms PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oms RCSB]</span>
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}}
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'''Structure determination by MAD: E.coli Trigger Factor binding at the ribosomal exit tunnel.'''
'''Structure determination by MAD: E.coli Trigger Factor binding at the ribosomal exit tunnel.'''
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[[Category: Gajhede, M.]]
[[Category: Gajhede, M.]]
[[Category: Kristensen, O.]]
[[Category: Kristensen, O.]]
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[[Category: alpha-beta structure]]
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[[Category: Alpha-beta structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:02:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:47:27 2008''
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Revision as of 01:02, 3 May 2008

Image:1oms.gif

Template:STRUCTURE 1oms

Structure determination by MAD: E.coli Trigger Factor binding at the ribosomal exit tunnel.


Overview

The exit tunnel region of the ribosome is well established as a focal point for interaction between the components that guide the fate of nascent polypeptides. One of these, the chaperone trigger factor (TF), associates with the 50S ribosomal subunit through its N-terminal domain. Targeting of TF to ribosomes is crucial to achieve its remarkable efficiency in protein folding. A similar tight coupling to translation is found in signal recognition particle (SRP)-dependent protein translocation. Here, we report crystal structures of the E. coli TF ribosome binding domain. TF is structurally related to the Hsp33 chaperone but has a prominent ribosome anchor located as a tip of the molecule. This tip includes the previously established unique TF signature motif. Comparison reveals that this feature is not found in SRP structures. We identify a conserved helical kink as a hallmark of the TF structure that is most likely critical to ensure ribosome association.

About this Structure

1OMS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Chaperone binding at the ribosomal exit tunnel., Kristensen O, Gajhede M, Structure. 2003 Dec;11(12):1547-56. PMID:14656439 Page seeded by OCA on Sat May 3 04:02:22 2008

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