1oo0

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[[Image:1oo0.gif|left|200px]]
[[Image:1oo0.gif|left|200px]]
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{{Structure
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|PDB= 1oo0 |SIZE=350|CAPTION= <scene name='initialview01'>1oo0</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1oo0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= MAGO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]), TSU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
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|DOMAIN=
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{{STRUCTURE_1oo0| PDB=1oo0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oo0 OCA], [http://www.ebi.ac.uk/pdbsum/1oo0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oo0 RCSB]</span>
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'''Crystal structure of the Drosophila Mago nashi-Y14 complex'''
'''Crystal structure of the Drosophila Mago nashi-Y14 complex'''
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[[Category: Shi, H.]]
[[Category: Shi, H.]]
[[Category: Xu, R M.]]
[[Category: Xu, R M.]]
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[[Category: exon junction complex]]
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[[Category: Exon junction complex]]
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[[Category: protein complex]]
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[[Category: Protein complex]]
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[[Category: rna recognition motif]]
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[[Category: Rna recognition motif]]
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[[Category: splicing]]
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[[Category: Splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:05:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:48:00 2008''
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Revision as of 01:05, 3 May 2008

Image:1oo0.gif

Template:STRUCTURE 1oo0

Crystal structure of the Drosophila Mago nashi-Y14 complex


Overview

Pre-mRNA splicing is essential for generating mature mRNA and is also important for subsequent mRNA export and quality control. The splicing history is imprinted on spliced mRNA through the deposition of a splicing-dependent multiprotein complex, the exon junction complex (EJC), at approximately 20 nucleotides upstream of exon-exon junctions. The EJC is a dynamic structure containing proteins functioning in the nuclear export and nonsense-mediated decay of spliced mRNAs. Mago nashi (Mago) and Y14 are core components of the EJC, and they form a stable heterodimer that strongly associates with spliced mRNA. Here we report a 1.85 A-resolution structure of the Drosophila Mago-Y14 complex. Surprisingly, the structure shows that the canonical RNA-binding surface of the Y14 RNA recognition motif (RRM) is involved in extensive protein-protein interactions with Mago. This unexpected finding provides important insights for understanding the molecular mechanisms of EJC assembly and RRM-mediated protein-protein interactions.

About this Structure

1OO0 is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Drosophila Mago nashi-Y14 complex., Shi H, Xu RM, Genes Dev. 2003 Apr 15;17(8):971-6. PMID:12704080 Page seeded by OCA on Sat May 3 04:05:12 2008

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OCA

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