1ook

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ook.gif|left|200px]]
[[Image:1ook.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ook |SIZE=350|CAPTION= <scene name='initialview01'>1ook</scene>, resolution 2.30&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ook", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TYS:SULFONATED+TYROSINE'>TYS</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= GP1BA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ook| PDB=1ook | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ook FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ook OCA], [http://www.ebi.ac.uk/pdbsum/1ook PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ook RCSB]</span>
+
-
}}
+
'''Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin'''
'''Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin'''
Line 32: Line 29:
[[Category: Ruggeri, Z M.]]
[[Category: Ruggeri, Z M.]]
[[Category: Varughese, K I.]]
[[Category: Varughese, K I.]]
-
[[Category: leucine rich repeat]]
+
[[Category: Leucine rich repeat]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:06:17 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:48:12 2008''
+

Revision as of 01:06, 3 May 2008

Image:1ook.gif

Template:STRUCTURE 1ook

Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin


Contents

Overview

Thrombin bound to platelets contributes to stop bleeding and, in pathological conditions, may cause vascular thrombosis. We have determined the structure of platelet glycoprotein Ibalpha (GpIbalpha) bound to thrombin at 2.3 angstrom resolution and defined two sites in GpIbalpha that bind to exosite II and exosite I of two distinct alpha-thrombin molecules, respectively. GpIbalpha occupancy may be sequential, as the site binding to alpha-thrombin exosite I appears to be cryptic in the unoccupied receptor but exposed when a first thrombin molecule is bound through exosite II. These interactions may modulate alpha-thrombin function by mediating GpIbalpha clustering and cleavage of protease-activated receptors, which promote platelet activation, while limiting fibrinogen clotting through blockade of exosite I.

Disease

Known disease associated with this structure: Bernard-Soulier syndrome, type A OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672]

About this Structure

1OOK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha., Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, Ruggeri ZM, Science. 2003 Jul 11;301(5630):218-21. PMID:12855810 Page seeded by OCA on Sat May 3 04:06:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ook"
Personal tools