5b7w
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b7w OCA], [http://pdbe.org/5b7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b7w RCSB], [http://www.ebi.ac.uk/pdbsum/5b7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b7w ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b7w OCA], [http://pdbe.org/5b7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b7w RCSB], [http://www.ebi.ac.uk/pdbsum/5b7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b7w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | As an important bacterial second messenger, bis-(3',5')-cyclic diguanylate (cyclic di-GMP or c-di-GMP) has been implicated in numerous biological activities, including biofilm formation, motility, survival and virulence. These processes are manipulated by the binding of c-di-GMP to its receptors. XC_3703 from the plant pathogen Xanthomonas campestris pv. campestris, which belongs to the YajQ family of proteins, has recently been identified as a potential c-di-GMP receptor. XC_3703, together with XC_2801, functions as a transcription factor activating virulence-related genes, which can be reversed by the binding of c-di-GMP to XC_3703. However, the structural basis of how c-di-GMP regulates XC_3703 remains elusive. In this study, the structure of XC_3703 was determined to 2.1 A resolution using the molecular-replacement method. The structure of XC_3703 consists of two domains adopting the same topology, which is similar to that of the RNA-recognition motif (RRM). Arg65, which is conserved among the c-di-GMP-binding subfamily of the YajQ family of proteins, together with Phe80 in domain II, forms a putative c-di-GMP binding site. | ||
| + | |||
| + | Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv. campestris.,Zhao Z, Wu Z, Zhang J Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):720-5. doi:, 10.1107/S2053230X16013017. Epub 2016 Aug 26. PMID:27599864<ref>PMID:27599864</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5b7w" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:21, 21 September 2016
Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv.campestris
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