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Thiolase

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*Acetoacetyl-CoA thiolase complex
*Acetoacetyl-CoA thiolase complex
-
**[[1dm3]], [[1dlv – ZrACT + CoA<br />
+
**[[1dm3]], [[1dlv]] – ZrACT + CoA<br />
**[[2wkt]], [[2wkv]], [[2wl4]], [[2wl5]], [[2vtz]], [[1m3z]] – ZrACT (mutant) + CoA<br />
**[[2wkt]], [[2wkv]], [[2wl4]], [[2wl5]], [[2vtz]], [[1m3z]] – ZrACT (mutant) + CoA<br />
**[[1m1o]] - ZrACT (mutant) + acetoacetyl-CoA<br />
**[[1m1o]] - ZrACT (mutant) + acetoacetyl-CoA<br />
**[[2vu0]], [[1nl7]] - ZrACT + CoA<br />
**[[2vu0]], [[1nl7]] - ZrACT + CoA<br />
**[[2vu1]], [[2vu2]], [[1ou6]] - ZrACT + pantheteine-11-pivalate<br />
**[[2vu1]], [[2vu2]], [[1ou6]] - ZrACT + pantheteine-11-pivalate<br />
-
**]]1wl4]] – hACT cytosolic + CoA <br />
+
**[[1wl4]] – hACT cytosolic + CoA <br />
**[[4xl4]] – CaACT + CoA <br />
**[[4xl4]] – CaACT + CoA <br />

Revision as of 22:52, 6 October 2017

Human 3-ketoacyl-CoA complex with CoA and ethylene glycol(PDB code 4c2j).

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3D Structures of Thiolase

Updated on 06-October-2017 {{#tree:id=OrganizedByTopic|openlevels=0|

  • 3-ketoacyl-CoA thiolase
    • 2wu9, 2c7y, 2c7z – KCT peroxisomal residues 36-462 – Arabidopsis thaliana
    • 2wua - KCT peroxisomal residues 17-449 (mutant) – sunflower
    • 2iik – hKCT peroxisomal – human
    • 4c2k – hKCT mitochondrial
    • 4c2j – hKCT mitochondrial + CoA
    • 3goa – KCT – Salmonella typhimurium
    • 5lp7 – KCT – Bacillus subtilis
    • 1afw, 1pxt – yKCT peroxisomal – yeast
    • 5cbq – MsKCT – Mycobacterium smegmatis
    • 4w61 – ReKCT – Ralstonia eutropha
    • 4ubw – MtKCT – Mycobacterium tuberculosis
  • 3-ketoacyl-CoA thiolase complex
    • 3w15 - yKCT peroxisomal residues 27-396 + peroxiomal membrane protein PEX21 + peroxisomal targeting signal receptor
    • 2d3t – PfKCT + fatty oxidation complex β subunit – Pseudomonas fragi
    • 1wdk, 1wdl, 1wdm - PfKCT + fatty oxidation complex α subunit
    • 5bz4 – MsKCT + CoA
    • 4ubt – MtKCT (mutant) + CoA + steroid
    • 4ubu – MtKCT (mutant) + CoA
    • 4ubv – MtKCT + CoA + acetyl CoA
  • Acetoacetyl-CoA thiolase
  • Acetoacetyl-CoA thiolase complex

}}

References

  1. ↑ Sundaramoorthy R, Micossi E, Alphey MS, Germain V, Bryce JH, Smith SM, Leonard GA, Hunter WN. The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation. J Mol Biol. 2006 Jun 2;359(2):347-57. Epub 2006 Mar 29. PMID:16630629 doi:http://dx.doi.org/10.1016/j.jmb.2006.03.032
  2. ↑ Soto G, Stritzler M, Lisi C, Alleva K, Pagano ME, Ardila F, Mozzicafreddo M, Cuccioloni M, Angeletti M, Ayub ND. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. J Exp Bot. 2011 Nov;62(15):5699-711. doi: 10.1093/jxb/err287. Epub 2011 Sep 9. PMID:21908473 doi:http://dx.doi.org/10.1093/jxb/err287
  3. ↑ Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK. The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3212-25. doi:, 10.1107/S1399004714023827. Epub 2014 Nov 22. PMID:25478839 doi:http://dx.doi.org/10.1107/S1399004714023827

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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