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Thioredoxin
From Proteopedia
(Difference between revisions)
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**[[2hxk]], [[2ifq]], [[2iiy]] – hTrx S-nitroso<br /> | **[[2hxk]], [[2ifq]], [[2iiy]] – hTrx S-nitroso<br /> | ||
**[[4oo5]] - hTrx S-nitroso (mutant)<br /> | **[[4oo5]] - hTrx S-nitroso (mutant)<br /> | ||
| - | **[[1auc]], [[1ert]], [[1eru]] | + | **[[1auc]], [[1ert]], [[1eru]] - hTrx<br /> |
| + | **[[1trs]], [[1tru]], [[1trv]], [[1trw]], [[3trx]], [[4trx]] - hTrx - NMR<br /> | ||
**[[3hxs]] – BfTrx fragment – ''Bacteroides fragilis''<br /> | **[[3hxs]] – BfTrx fragment – ''Bacteroides fragilis''<br /> | ||
**[[3hyp]] - BfrxI fragment (mutant)<br /> | **[[3hyp]] - BfrxI fragment (mutant)<br /> | ||
| Line 51: | Line 52: | ||
**[[2voc]] - BsTrx (mutant) – ''Bacillus subtilis''<br /> | **[[2voc]] - BsTrx (mutant) – ''Bacillus subtilis''<br /> | ||
**[[2gzy]], [[2gzz]] – BsTrx – NMR<br /> | **[[2gzy]], [[2gzz]] – BsTrx – NMR<br /> | ||
| - | **[[2h6x]], [[2trx]], [[1srx]] – EcTrx<br /> | + | **[[2h6x]], [[2trx]], [[1srx]] – EcTrx – ''Escherichia coli''<br /> |
**[[1xoa]], [[1xob]] – EcTrx - NMR<br /> | **[[1xoa]], [[1xob]] – EcTrx - NMR<br /> | ||
| + | **[[2tir]], [[4hua]], [[4hu9]], [[4hu7]] - EcTrx (mutant) <br /> | ||
**[[1m7t]] – hTrx/EcTrx chimera - NMR<br /> | **[[1m7t]] – hTrx/EcTrx chimera - NMR<br /> | ||
**[[3emx]] – Trx – ''Aeropyrum pernix''<br /> | **[[3emx]] – Trx – ''Aeropyrum pernix''<br /> | ||
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**[[1quw]] – Trx – ''Bacillus acidocaldarius'' – NMR<br /> | **[[1quw]] – Trx – ''Bacillus acidocaldarius'' – NMR<br /> | ||
**[[2l5l]] – Trx – ''Bacteroides vulgatus'' – NMR<br /> | **[[2l5l]] – Trx – ''Bacteroides vulgatus'' – NMR<br /> | ||
| - | **[[2tir]], [[4hua]], [[4hu9]], [[4hu7]] - EcTrx (mutant) – ''Escherichia coli''<br /> | ||
**[[2xbi]] – SmTrx – ''Schistosoma mansoni''<br /> | **[[2xbi]] – SmTrx – ''Schistosoma mansoni''<br /> | ||
**[[2xbq]], [[2xc2]] – SmTrx (mutant)<br /> | **[[2xbq]], [[2xc2]] – SmTrx (mutant)<br /> | ||
| Line 91: | Line 92: | ||
**[[4cw9]] - Trx (mutant) – ''Entamoeba histolytica''<br /> | **[[4cw9]] - Trx (mutant) – ''Entamoeba histolytica''<br /> | ||
**[[4wxt]] - Trx – ''Mycobacterium avium''<br /> | **[[4wxt]] - Trx – ''Mycobacterium avium''<br /> | ||
| + | **[[5dbq]] - Trx – velvetbean caterpillar<br /> | ||
*Thioredoxin complexes | *Thioredoxin complexes | ||
| Line 113: | Line 115: | ||
**[[1zyq]] – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase+ATP<br /> | **[[1zyq]] – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase+ATP<br /> | ||
**[[1x9m]], [[1x9s]], [[1x9w]] – EpTrx-1+DNA primer+DNA template+DNA polymerase+N-2-acetylaminofluorene-adducted DNA<br /> | **[[1x9m]], [[1x9s]], [[1x9w]] – EpTrx-1+DNA primer+DNA template+DNA polymerase+N-2-acetylaminofluorene-adducted DNA<br /> | ||
| - | **[[1t8e]] – EpTrx-1 +DNA primer+DNA template+DNA polymerase+dCTP<br /> | + | **[[1t8e]], [[1skr]], [[1sks]], [[1skw]], [[1sl0]], [[1sl1]], [[1sl2]], [[1t7p]] – EpTrx-1 +DNA primer+DNA template+DNA polymerase+dCTP<br /> |
| - | **[[1tk0]] – EpTrx-1+DNA primer+DNA template+DNA polymerase+ | + | **[[1tk0]], [[1tk8]], [[1tkd]] – EpTrx-1+DNA primer+DNA template+DNA polymerase+ nucleotide +8-oxo-guanosine<br /> |
**[[1tk5]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+8-oxo-guanosine<br /> | **[[1tk5]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+8-oxo-guanosine<br /> | ||
| - | **[[1tk8]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+dAMP+8-oxo-guanosine<br /> | ||
| - | **[[1tkd]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+dCMP+8-oxo-guanosine<br /> | ||
| - | **[[1skr]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+ddATP<br /> | ||
| - | **[[1sks]], [[1skw]], [[1sl0]], [[1sl1]], [[1sl2]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+thymine<br /> | ||
| - | **[[1t7p]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+ddAMP+ddGTP<br /> | ||
**[[2bto]] – Trx-1+tubulin btuba – ''Prosthecobacter dejongeii''<br /> | **[[2bto]] – Trx-1+tubulin btuba – ''Prosthecobacter dejongeii''<br /> | ||
**[[1oaz]] – Trx-1+immunoglobulin E – rat<br /> | **[[1oaz]] – Trx-1+immunoglobulin E – rat<br /> | ||
Revision as of 09:05, 13 September 2016
Image:1ert.png
Crystal Structure of Thioredoxin 1ert
Contents |
Function
Thioredoxin (Trx) is an enzyme which facilitates, in its reduced form, the reduction of proteins by cysteine thiol-disulfide exchange[1]. They contain a CXXC motif.
- Trx-1 is a mammalian cellular protein.
- Trx-2 is mitochondria-specific.
In higher plants, Trx are divided to 6 groups based on their sequence. Trx M, X and Y are found in prokaryotes while F, H and O are found in eukaryotes.
Relevance
Serum Trx level is a predictor of steatohepatitis[2].
Disease
Trx is involved in a wide range of human diseases and conditions including cancer, viral diseases, aging, cardiac conditions and more[3].
Structural highlights
3D Structures of Thioredoxin
Updated on 13-September-2016
References
- ↑ Gleason FK, Holmgren A. Thioredoxin and related proteins in procaryotes. FEMS Microbiol Rev. 1988 Dec;4(4):271-97. PMID:3152490
- ↑ Sumida Y, Nakashima T, Yoh T, Furutani M, Hirohama A, Kakisaka Y, Nakajima Y, Ishikawa H, Mitsuyoshi H, Okanoue T, Kashima K, Nakamura H, Yodoi J. Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. J Hepatol. 2003 Jan;38(1):32-8. PMID:12480557
- ↑ Burke-Gaffney A, Callister ME, Nakamura H. Thioredoxin: friend or foe in human disease? Trends Pharmacol Sci. 2005 Aug;26(8):398-404. PMID:15990177 doi:http://dx.doi.org/10.1016/j.tips.2005.06.005
