Thioredoxin Reductase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3qfa' size='350' side='right' caption='Human Thioredoxin reductase dimer ( | + | <StructureSection load='3qfa' size='350' side='right' caption='Human Thioredoxin reductase dimer (cyan, green) complex with thioredoxin (yellow, pink), glycerol and FAD (PDB entry [[3qfa]])' scene='43/433123/Cv/2'> |
== Function == | == Function == | ||
[[Thioredoxin Reductase]] (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. '''TrxR-2''' is mitochondrial. For more details see [[User:Sarah Abdalla/Thioredoxin Reductase]]. | [[Thioredoxin Reductase]] (TrxR) is an enzyme which reduces thioredoxin using NADPH<ref>PMID:11012661</ref>. '''TrxR-2''' is mitochondrial. For more details see [[User:Sarah Abdalla/Thioredoxin Reductase]]. | ||
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== Structural highlights == | == Structural highlights == | ||
| - | TrxR and Trx form an <scene name='43/433123/Cv/3'>intramolecular Cys-Cys bond</scene><ref>PMID:21750537</ref>. | + | TrxR and Trx form an <scene name='43/433123/Cv/3'>intramolecular Cys-Cys bond</scene><ref>PMID:21750537</ref>. <scene name='43/433123/Cv/5'>FAD binding site</scene>. Water molecules shown as red spheres. |
</StructureSection> | </StructureSection> | ||
Revision as of 11:38, 13 September 2016
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3D Structures of Thioredoxin Reductase
Updated on 13-September-2016
References
- ↑ Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000 Oct;267(20):6102-9. PMID:11012661
- ↑ Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. doi: 10.1210/jc.2013-3844. Epub, 2014 Mar 6. PMID:24601690 doi:http://dx.doi.org/10.1210/jc.2013-3844
- ↑ Fritz-Wolf K, Kehr S, Stumpf M, Rahlfs S, Becker K. Crystal structure of the human thioredoxin reductase-thioredoxin complex. Nat Commun. 2011 Jul 12;2:383. doi: 10.1038/ncomms1382. PMID:21750537 doi:10.1038/ncomms1382
