Tissue factor pathway inhibitor
From Proteopedia
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<StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domain II (grey) complex with trypsin (pink) and Ca+2 ion (PDB code [[1tfx]]) comp' scene=''> | <StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domain II (grey) complex with trypsin (pink) and Ca+2 ion (PDB code [[1tfx]]) comp' scene=''> | ||
| - | '''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel β sheet followed by an α helix. Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa. | ||
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== Function == | == Function == | ||
| + | '''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa<ref>PMID:9112630</ref>. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel β sheet followed by an α helix. Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa. | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| - | + | The expression of hTFPI-2 in tumors is inversely related to their malignancy<ref>PMID:18000791</ref>. TFPI inhibitors are investigated as therapeutic agents agains hemophilia<ref>PMID:27207416</ref>. | |
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:21, 14 September 2016
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3D Structures of tissue factor pathway inhibitor
Updated on 14-September-2016
1adz – hTFPI-1 kunitz domain II (mutant) – human - NMR
1irh – hTFPI-1 kunitz domain III - NMR
1tfx – hTFPI-1 kunitz domain II + trypsin
1zr0 – hTFPI-2 kunitz domain I + trypsin
4dtg – hTFPI-1 kunitz domain II + antibody
4bqd – hTFPI-1 kunitz domain I + peptide
References
- ↑ Kato H. Tissue factor pathway inhibitor; its structure, function and clinical significance. Pol J Pharmacol. 1996 Jan-Feb;48(1):67-72. PMID:9112630
- ↑ Sierko E, Wojtukiewicz MZ, Kisiel W. The role of tissue factor pathway inhibitor-2 in cancer biology. Semin Thromb Hemost. 2007 Oct;33(7):653-9. PMID:18000791 doi:http://dx.doi.org/10.1055/s-2007-991532
- ↑ Diamond SL. Flow and delta-P dictate where thrombin, fibrin, and von Willebrand Factor will be found. Thromb Res. 2016 May;141 Suppl 2:S22-4. doi: 10.1016/S0049-3848(16)30357-7. PMID:27207416 doi:http://dx.doi.org/10.1016/S0049-3848(16)30357-7
