5t7o
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE== | |
| - | + | <StructureSection load='5t7o' size='340' side='right' caption='[[5t7o]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t7o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T7O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=THG:(6S)-5,6,7,8-TETRAHYDROFOLATE'>THG</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | |
| - | [[Category: | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tc00.1047053509153.90 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t7o OCA], [http://pdbe.org/5t7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t7o RCSB], [http://www.ebi.ac.uk/pdbsum/5t7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t7o ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q4DLS1_TRYCC Q4DLS1_TRYCC]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Trycc]] | ||
[[Category: Bonucci, A]] | [[Category: Bonucci, A]] | ||
| + | [[Category: Iacono, L Dello]] | ||
[[Category: Mangani, S]] | [[Category: Mangani, S]] | ||
| - | [[Category: | + | [[Category: Pisa, F Di]] |
| - | [[Category: | + | [[Category: Folate metabolism]] |
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Trypanosoma cruzi]] | ||
| + | [[Category: Trypanosomatidic infection]] | ||
Revision as of 14:25, 15 November 2017
Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE
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