Topoisomerase binding protein
From Proteopedia
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| - | <StructureSection load='3ueo' size='350' side='right' caption='Structure of human topoisomerase binding protein BRCT 4-5 domain tetramer (gray, pink) complex with phospho-peptide (cyan) (PDB entry [[3ueo]])' scene=''> | + | <StructureSection load='3ueo' size='350' side='right' caption='Structure of human topoisomerase binding protein 1 BRCT 4-5 domain tetramer (gray, pink) complex with phospho-peptide (cyan) (PDB entry [[3ueo]])' scene=''> |
| + | == Function == | ||
| + | '''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks<ref>PMID:9461304</ref>. | ||
| - | + | == Structural highlights == | |
| + | TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides. The phospho-peptide interacts with BRCT4 and BRCT5 of both monomers<ref>PMID:23891287</ref>. | ||
==3D structures of topoisomerase binding protein== | ==3D structures of topoisomerase binding protein== | ||
Revision as of 10:03, 18 September 2016
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