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5e5m
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse CTLA-4 in complex with nanobody== | |
| - | + | <StructureSection load='5e5m' size='340' side='right' caption='[[5e5m]], [[Resolution|resolution]] 2.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5e5m]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E5M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e56|5e56]], [[5e03|5e03]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5m OCA], [http://pdbe.org/5e5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e5m RCSB], [http://www.ebi.ac.uk/pdbsum/5e5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5m ProSAT]</span></td></tr> |
| - | [[Category: Fedorov, A | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CTLA4_MOUSE CTLA4_MOUSE]] Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Almo, S C]] | ||
| + | [[Category: Bonanno, J B]] | ||
| + | [[Category: Fedorov, A A]] | ||
| + | [[Category: Fedorov, E V]] | ||
[[Category: Samanta, D]] | [[Category: Samanta, D]] | ||
| - | [[Category: | + | [[Category: Immune system]] |
| - | [[Category: | + | [[Category: The complex of mouse ctla-4 with its nanobody]] |
| + | [[Category: Treatment of metastatic melanoma]] | ||
Revision as of 17:37, 19 October 2016
Crystal structure of mouse CTLA-4 in complex with nanobody
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