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1oxb
From Proteopedia
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'''Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)''' | '''Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)''' | ||
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[[Category: West, A H.]] | [[Category: West, A H.]] | ||
[[Category: Xu, Q.]] | [[Category: Xu, Q.]] | ||
| - | [[Category: | + | [[Category: Histidine-containing phosphotransfer protein]] |
| - | [[Category: | + | [[Category: Hpt domain]] |
| - | [[Category: | + | [[Category: Phosphorelay protein]] |
| - | [[Category: | + | [[Category: Response regulator]] |
| - | [[Category: | + | [[Category: Sln1p]] |
| - | [[Category: | + | [[Category: Two-component signaling protein]] |
| - | [[Category: | + | [[Category: Ypd1p]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:32 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:23, 3 May 2008
Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)
Overview
In Saccharomyces cerevisiae, a branched multistep phosphorelay signaling pathway regulates cellular adaptation to hyperosmotic stress. YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7). These four proteins are evolutionarily related to the well-characterized "two-component" regulatory proteins from bacteria. Although structural information is available for many two-component signaling proteins, there are very few examples of complexes between interacting phosphorelay partners. Here we report the first crystal structure of a prototypical monomeric histidine-containing phosphotransfer (HPt) protein YPD1 in complex with its upstream phosphodonor, the response regulator domain associated with SLN1.
About this Structure
1OXB is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
The yeast YPD1/SLN1 complex: insights into molecular recognition in two-component signaling systems., Xu Q, Porter SW, West AH, Structure. 2003 Dec;11(12):1569-81. PMID:14656441 Page seeded by OCA on Sat May 3 04:23:32 2008
