Transferrin receptor
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_1suv| PDB=1suv | SIZE=400| SCENE= |right|CAPTION=Human transferrin receptor ectodomain dimer (grey and green) complex with transferrin N-lobe (pink and yellow) and C-lobe (cyan and magenta) and carbonate, [[1suv]] }} | ||
| + | <StructureSection load='1suv' size='340' side='right' caption='Human transferrin receptor ectodomain dimer (grey and green) complex with transferrin N-lobe (pink and yellow) and C-lobe (cyan and magenta) and carbonate, [[1suv]]' scene='' > | ||
== Function == | == Function == | ||
'''Transferrin receptor''' (TfR) imports iron into the cell by receptor-mediated endocytosis of [[Transferrin|transferrin]]-iron complex. TfR is regulated by intracellular iron concentration. The amount of TfR expressed on the cell is proportional to the cell’s need for iron. The TfR has selective affinity for diferric-transferrin. The TfR-transferrin complex is internalized by the cell and iron is released to the cytosol. The TfR-apotransferrin complex returns to the extracellular surface where the apotransferrin dissociates and is replaced by diferric-transferrin<ref>PMID:10192390</ref>. | '''Transferrin receptor''' (TfR) imports iron into the cell by receptor-mediated endocytosis of [[Transferrin|transferrin]]-iron complex. TfR is regulated by intracellular iron concentration. The amount of TfR expressed on the cell is proportional to the cell’s need for iron. The TfR has selective affinity for diferric-transferrin. The TfR-transferrin complex is internalized by the cell and iron is released to the cytosol. The TfR-apotransferrin complex returns to the extracellular surface where the apotransferrin dissociates and is replaced by diferric-transferrin<ref>PMID:10192390</ref>. | ||
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== Relevance == | == Relevance == | ||
TfR is a potential determinant of iron loading in congenital anemias<ref>PMID:10468869</ref>. | TfR is a potential determinant of iron loading in congenital anemias<ref>PMID:10468869</ref>. | ||
| - | + | == Structural highlights == | |
==3D structures of transferrin receptor== | ==3D structures of transferrin receptor== | ||
Revision as of 08:28, 28 November 2016
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