5lvq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human PCAF bromodomain in complex with compound-D (CPD-D), N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide== | |
| - | + | <StructureSection load='5lvq' size='340' side='right' caption='[[5lvq]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lvq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LVQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LX:N-METHYL-2-(TETRAHYDRO-2H-PYRAN-4-YLOXY)BENZAMIDE'>2LX</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lvq OCA], [http://pdbe.org/5lvq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lvq RCSB], [http://www.ebi.ac.uk/pdbsum/5lvq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lvq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KAT2B_HUMAN KAT2B_HUMAN]] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:8684459</ref> <ref>PMID:9707565</ref> <ref>PMID:10675335</ref> <ref>PMID:23932781</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Histone acetyltransferase]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
[[Category: Chaikuad, A]] | [[Category: Chaikuad, A]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Filippakopoulos, P]] | ||
| + | [[Category: Hopkins, A L]] | ||
[[Category: Knapp, S]] | [[Category: Knapp, S]] | ||
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Acetylation]] |
| - | [[Category: | + | [[Category: Acetyllysine]] |
| - | [[Category: | + | [[Category: Bromodomain]] |
| - | [[Category: | + | [[Category: Epigenetic]] |
| - | [[Category: | + | [[Category: Histone]] |
| - | [[Category: | + | [[Category: Histone acetyltransferase kat2b]] |
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 18:48, 26 October 2016
Crystal structure of human PCAF bromodomain in complex with compound-D (CPD-D), N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide
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Categories: Histone acetyltransferase | Arrowsmith, C H | Bountra, C | Chaikuad, A | Delft, F von | Edwards, A M | Filippakopoulos, P | Hopkins, A L | Knapp, S | Structural genomic | Acetylation | Acetyllysine | Bromodomain | Epigenetic | Histone | Histone acetyltransferase kat2b | Signaling protein | Transferase
