This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5t3m
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7== | |
| - | + | <StructureSection load='5t3m' size='340' side='right' caption='[[5t3m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t3m]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T3M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3m OCA], [http://pdbe.org/5t3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t3m RCSB], [http://www.ebi.ac.uk/pdbsum/5t3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3m ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TXH4_HAPSC TXH4_HAPSC]] This lethal neurotoxin acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (Nav), with an IC(50) of 30 nM in rat DRG neurons. Preferentially inhibits neuronal voltage-gated sodium channel subtype hNav1.7/SCN9A (IC(50) is 26 nM), rNav1.2/SCN2A (IC(50) is 150 nM), and rNav1.3/SCN3A (IC(50) is 338 nM), compared with muscle subtypes rNav1.4/SCN4A and hNav1.5/SCN5A (IC(50) is > 10 uM). Inhibits activation of sodium channel by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.<ref>PMID:12228241</ref> <ref>PMID:18628201</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Mobli, M]] | ||
[[Category: Rahnama, S]] | [[Category: Rahnama, S]] | ||
| - | [[Category: Mobli, M]] | ||
[[Category: Sharma, G]] | [[Category: Sharma, G]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 09:41, 13 September 2017
Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7
| |||||||||||
Categories: Mobli, M | Rahnama, S | Sharma, G | Toxin
