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1oyu

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[[Image:1oyu.jpg|left|200px]]
[[Image:1oyu.jpg|left|200px]]
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{{Structure
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|PDB= 1oyu |SIZE=350|CAPTION= <scene name='initialview01'>1oyu</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1oyu", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span>
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{{STRUCTURE_1oyu| PDB=1oyu | SCENE= }}
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|RELATEDENTRY=[[261l|261L]], [[262l|262L]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oyu OCA], [http://www.ebi.ac.uk/pdbsum/1oyu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oyu RCSB]</span>
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'''Long-Distance conformational changes in a protein engineered by modulated sequence duplication'''
'''Long-Distance conformational changes in a protein engineered by modulated sequence duplication'''
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[[Category: Matthews, B W.]]
[[Category: Matthews, B W.]]
[[Category: Sagermann, M.]]
[[Category: Sagermann, M.]]
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[[Category: design of structural switch]]
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[[Category: Design of structural switch]]
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[[Category: protein design]]
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[[Category: Protein design]]
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[[Category: sequence duplication]]
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[[Category: Sequence duplication]]
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[[Category: tandem repeat]]
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[[Category: Tandem repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:26:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:52:22 2008''
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Revision as of 01:26, 3 May 2008

Image:1oyu.jpg

Template:STRUCTURE 1oyu

Long-Distance conformational changes in a protein engineered by modulated sequence duplication


Overview

There are few, if any, known instances in which a biological signal is transmitted via a large conformational change through the body of a protein. We describe here a mutant of T4 lysozyme that was engineered to permit structural change at a distance. The design uses a tandem sequence repeat that makes it possible to transmit large-scale structural changes from one end of an alpha-helix to the other over a distance of 17-25 A. The method should be of general applicability and may make it possible to introduce a mutation at one site in a protein that will induce large-scale changes in the structure at a spatially remote site.

About this Structure

1OYU is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Long-distance conformational changes in a protein engineered by modulated sequence duplication., Sagermann M, Gay L, Matthews BW, Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9191-5. Epub 2003 Jul 17. PMID:12869697 Page seeded by OCA on Sat May 3 04:26:45 2008

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