1oyx

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[[Image:1oyx.jpg|left|200px]]
[[Image:1oyx.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1oyx |SIZE=350|CAPTION= <scene name='initialview01'>1oyx</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1oyx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= L3MBTL OR L3MBT OR KIAA0681 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1oyx| PDB=1oyx | SCENE= }}
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|RELATEDENTRY=[[1oz2|1OZ2]], [[1oz3|1OZ3]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oyx OCA], [http://www.ebi.ac.uk/pdbsum/1oyx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oyx RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM'''
'''CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM'''
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[[Category: Tereshko, V.]]
[[Category: Tereshko, V.]]
[[Category: Wang, W K.]]
[[Category: Wang, W K.]]
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[[Category: propeller]]
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[[Category: Propeller]]
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[[Category: transcription repressor]]
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[[Category: Transcription repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:26:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:52:25 2008''
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Revision as of 01:27, 3 May 2008

Image:1oyx.jpg

Template:STRUCTURE 1oyx

CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM


Overview

We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies. Interdigitation between the extended arms and cores of the mbt repeats results in a three-leaved propeller-like architecture, containing a central cavity. We have identified one ligand binding pocket per mbt repeat, which accommodates either the morphilino ring of MES or the proline ring of the C-terminal peptide segment, within a cavity lined by aromatic amino acids. Strikingly, phenotypic alterations resulting from point mutations or deletions in the mbt repeats of the related Drosophila SCM protein are clustered in and around the ligand binding pocket.

About this Structure

1OYX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets., Wang WK, Tereshko V, Boccuni P, MacGrogan D, Nimer SD, Patel DJ, Structure. 2003 Jul;11(7):775-89. PMID:12842041 Page seeded by OCA on Sat May 3 04:26:59 2008

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