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TRNA methyltransferase

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Line 31: Line 31:
*Complexes of tRNA guanine 37 N1 methyltransferase
*Complexes of tRNA guanine 37 N1 methyltransferase
-
**[[1uak]] – HiTrm + SAM <br />
+
**[[1uak]], [[4yvg]] – HiTrm + SAM <br />
**[[1ual]], [[1uam]] – HiTrm + SAH <br />
**[[1ual]], [[1uam]] – HiTrm + SAH <br />
**[[3axz]] – HiTrm + adenosine<br />
**[[3axz]] – HiTrm + adenosine<br />
**[[4mcb]], [[4mcc]], [[4mcd]] – HiTrm + inhibitor<br />
**[[4mcb]], [[4mcc]], [[4mcd]] – HiTrm + inhibitor<br />
 +
**[[4yvh]] – HiTrm + SFG <br />
 +
**[[4yvi]], [[4yvj]], [[4yvk]] – HiTrm + SFG + tRNA<br />
 +
**[[5d9f]], [[4ypw]], [[4ypx]], [[4ypy]], [[4ypz]], [[4yq0]], [[4yq1]], [[4yq2]], [[4yq3]], [[4yq4]], [[4yq5]], [[4yq6]], [[4yq7]], [[4yq8]], [[4yq9]], [[4yqa]], [[4yqb]], [[4yqc]], [[4yqg]], [[4yqi]], [[4yqj]], [[4yqk]], [[4yql]], [[4yqn]], [[4yqo]], [[4yqp]], [[4yqq]], [[4yqr]], [[4yqs]], [[4yqt]], [[4yqd]] – HiTrm + SAM competitive<br />
**[[1p9p]] – EcTrm + SAH – ''Escherichia coli'' <br />
**[[1p9p]] – EcTrm + SAH – ''Escherichia coli'' <br />
**[[2yx1]] – MjTrm + SFG – ''Methanocalcococcus jannaschii''<br />
**[[2yx1]] – MjTrm + SFG – ''Methanocalcococcus jannaschii''<br />
Line 41: Line 44:
**[[4ig6]] – ApTrm + SAH <br />
**[[4ig6]] – ApTrm + SAH <br />
**[[4gek]], [[4iwn]] – EcTrm + SAM derivative<br />
**[[4gek]], [[4iwn]] – EcTrm + SAM derivative<br />
 +
**[[5hr7]] – EcTrm + tRNA-Glu<br />
*'''tRNA guanine 46 N7 methyltransferase'''
*'''tRNA guanine 46 N7 methyltransferase'''
Line 51: Line 55:
*Complexes of tRNA guanine 46 N7 methyltransferase
*Complexes of tRNA guanine 46 N7 methyltransferase
-
**[[3ckk]] – Trm + SAM - human<br />
+
**[[3ckk]] – hTrm + SAM - human<br />
**[[3dxy]] – EcTrm + SAM <br />
**[[3dxy]] – EcTrm + SAM <br />
**[[3dxz]] – EcTrm + SAH <br />
**[[3dxz]] – EcTrm + SAH <br />
 +
 +
*Trm to O2 of cytidine 32
 +
 +
**[[4cnd]] – EcTrm (mutant)<br />
 +
**[[4xbo]] – EcTrm + SAH<br />
 +
**[[4cne]] – EcTrm (mutant) + SAH<br />
*'''tRNA cytidine 34 O2 methyltransferase'''
*'''tRNA cytidine 34 O2 methyltransferase'''
Line 73: Line 83:
**[[3tm4]] – PfTrm + SAM<br />
**[[3tm4]] – PfTrm + SAM<br />
-
*'''tRNA adenine N1 methyltransferase'''
+
*Trm M2G/M22G10
-
**[[2pwy]] – Trm – ''Thermos thermophilus''<br />
+
**[[5e71]] – TkTrm – Thermococcvus kodakarensis<br />
 +
**[[5e72]] – TkTrm + SAM<br />
 +
 
 +
*Trm to N1 of adenine 9
 +
 
 +
**[[5a7t]], [[5a7z]] – SaTrm – Sulfolobus acidocaldarius<br />
 +
**[[4cnf]] – SaTrm (mutant)<br />
 +
**[[5a7y]] – SaTrm + SAH<br />
 +
**[[4cng]] – SaTrm (mutant) + SAH<br />
 +
 
 +
*'''tRNA adenine 58 N1 methyltransferase'''
 +
 
 +
**[[2pwy]] – TtTrm – ''Thermus thermophilus''<br />
 +
**[[5c0o]], [[5c1i]] – TtTrm (mutant) + SAM<br />
 +
**[[5eqj]] – yTrm <br />
 +
**[[5erg]] – yTrm + SAM<br />
 +
**[[5ccb]], [[5cd1]] – hTrm + SAH + tRNA-Lys<br />
 +
**[[5ccx]] – hTrm + tRNA-Lys<br />
 +
 
 +
*Trm to uracil 34
 +
 
 +
**[[4qnx]] – EcTrm <br />
 +
**[[4qnu]], [[4qnv]] – EcTrm + SAM derivative<br />
*'''tRNA uracil 54 methyltransferase'''
*'''tRNA uracil 54 methyltransferase'''
**[[3bt7]] – yTrm + RNA<br />
**[[3bt7]] – yTrm + RNA<br />
 +
 +
*Trm9-TRM112
 +
 +
**[[5cm2]] – Trm – ''Yarrowia lipolytica''<br />
 +
 +
*Trm dual specificity
 +
 +
**[[4pl1]], [[4pl2]] – EcTrm (mutant) + SAM<br />
 +
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:31, 25 September 2016

Structure of tRNA methyltransferase for N1 of guanine 37 complex with S-adenosylhomocysteine (PDB entry 1uak)

Drag the structure with the mouse to rotate

3D structures of tRNA methyltransferase

Updated on 25-September-2016

References

  1. ↑ Swinehart WE, Jackman JE. Diversity in mechanism and function of tRNA methyltransferases. RNA Biol. 2015;12(4):398-411. doi: 10.1080/15476286.2015.1008358. PMID:25626150 doi:http://dx.doi.org/10.1080/15476286.2015.1008358
  2. ↑ Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK. Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition. EMBO J. 2003 Jun 2;22(11):2593-603. PMID:12773376 doi:10.1093/emboj/cdg269

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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