1p1y
From Proteopedia
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[[Image:1p1y.gif|left|200px]] | [[Image:1p1y.gif|left|200px]] | ||
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'''Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)''' | '''Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P1Y OCA]. | |
==Reference== | ==Reference== | ||
Crystal structure of a continuous three-dimensional DNA lattice., Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC, Chem Biol. 2004 Aug;11(8):1119-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15324813 15324813] | Crystal structure of a continuous three-dimensional DNA lattice., Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC, Chem Biol. 2004 Aug;11(8):1119-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15324813 15324813] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Birktoft, J J.]] | [[Category: Birktoft, J J.]] | ||
[[Category: Nowakowski, J.]] | [[Category: Nowakowski, J.]] | ||
[[Category: Paukstelis, P J.]] | [[Category: Paukstelis, P J.]] | ||
[[Category: Seeman, N C.]] | [[Category: Seeman, N C.]] | ||
| - | [[Category: | + | [[Category: Continuous three-dimensional dna lattice]] |
| - | [[Category: | + | [[Category: Parallel-stranded base pair]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:34:46 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:34, 3 May 2008
Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)
Overview
DNA has proved to be a versatile material for the rational design and assembly of nanometer scale objects. Here we report the crystal structure of a continuous three-dimensional DNA lattice formed by the self-assembly of a DNA 13-mer. The structure consists of stacked layers of parallel helices with adjacent layers linked through parallel-stranded base pairing. The hexagonal lattice geometry contains solvent channels that appear large enough to allow 3'-linked guest molecules into the crystal. We have successfully used these parallel base pairs to design and produce crystals with greatly enlarged solvent channels. This lattice may have applications as a molecular scaffold for structure determination of guest molecules, as a molecular sieve, or in the assembly of molecular electronics. Predictable non-Watson-Crick base pairs, like those described here, may present a new tool in structural DNA nanotechnology.
About this Structure
Full crystallographic information is available from OCA.
Reference
Crystal structure of a continuous three-dimensional DNA lattice., Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC, Chem Biol. 2004 Aug;11(8):1119-26. PMID:15324813 Page seeded by OCA on Sat May 3 04:34:46 2008
