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5kbz

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'''Unreleased structure'''
 
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The entry 5kbz is ON HOLD until Paper Publication
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==Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic==
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<StructureSection load='5kbz' size='340' side='right' caption='[[5kbz]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5kbz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KBZ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3B2:(14R)-14-HYDROXY-15,15-DIMETHYL-1-[5-({[(5-METHYL-1,2-OXAZOL-3-YL)METHYL]SULFANYL}METHYL)-1,2-OXAZOL-3-YL]-4,9,13-TRIOXO-2-THIA-5,8,12-TRIAZAHEXADECAN-16-YL+DIHYDROGEN+PHOSPHATE'>3B2</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hrr|3hrr]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Noranthrone_synthase Noranthrone synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.221 2.3.1.221] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kbz OCA], [http://pdbe.org/5kbz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kbz RCSB], [http://www.ebi.ac.uk/pdbsum/5kbz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kbz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PKSL1_ASPPA PKSL1_ASPPA]] Combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor norsolorinic acid anthrone (noranthrone) in the aflatoxin biosynthesis pathway. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase.<ref>PMID:15006741</ref> <ref>PMID:18403714</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Noranthrone synthase]]
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[[Category: Barajas, J F]]
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[[Category: Burkart, M D]]
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[[Category: Clair, J J.La]]
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[[Category: Jackson, D R]]
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[[Category: Moreno, G]]
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[[Category: Rivera, H]]
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[[Category: Shakya, G]]
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[[Category: Topper, C L]]
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[[Category: Townsend, C A]]
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[[Category: Tsai, S C]]
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[[Category: Vagstad, A]]
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[[Category: Aflatoxin]]
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[[Category: Cyclase]]
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[[Category: Dehydratase]]
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[[Category: Double hot dog fold]]
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[[Category: Polyketide]]
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[[Category: Polyketide synthase]]
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[[Category: Product template]]
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[[Category: Transcription]]

Revision as of 12:57, 10 May 2017

Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic

5kbz, resolution 1.80Å

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