1p3j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1p3j.gif|left|200px]]
[[Image:1p3j.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1p3j |SIZE=350|CAPTION= <scene name='initialview01'>1p3j</scene>, resolution 1.90&Aring;
+
The line below this paragraph, containing "STRUCTURE_1p3j", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=AP5:BIS(ADENOSINE)-5&#39;-PENTAPHOSPHATE'>AP5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ADK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1p3j| PDB=1p3j | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3j OCA], [http://www.ebi.ac.uk/pdbsum/1p3j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p3j RCSB]</span>
+
-
}}
+
'''Adenylate Kinase from Bacillus subtilis'''
'''Adenylate Kinase from Bacillus subtilis'''
Line 28: Line 25:
[[Category: Bae, E.]]
[[Category: Bae, E.]]
[[Category: Jr., G N.Phillips.]]
[[Category: Jr., G N.Phillips.]]
-
[[Category: zinc coordination]]
+
[[Category: Zinc coordination]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:38:24 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:54:23 2008''
+

Revision as of 01:38, 3 May 2008

Image:1p3j.gif

Template:STRUCTURE 1p3j

Adenylate Kinase from Bacillus subtilis


Overview

The crystal structures of adenylate kinases from the psychrophile Bacillus globisporus and the mesophile Bacillus subtilis have been solved and compared with that from the thermophile Bacillus stearothermophilus. This is the first example we know of where a trio of protein structures has been solved that have the same number of amino acids and a high level of identity (66-74%) and yet come from organisms with different operating temperatures. The enzymes were characterized for their own thermal denaturation and inactivation, and they exhibited the same temperature preferences as their source organisms. The structures of the three highly homologous, dynamic proteins with different temperature-activity profiles provide an opportunity to explore a molecular mechanism of cold and heat adaptation. Their analysis suggests that the maintenance of the balance between stability and flexibility is crucial for proteins to function at their environmental temperatures, and it is achieved by the modification of intramolecular interactions in the process of temperature adaptation.

About this Structure

1P3J is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structures and analysis of highly homologous psychrophilic, mesophilic, and thermophilic adenylate kinases., Bae E, Phillips GN Jr, J Biol Chem. 2004 Jul 2;279(27):28202-8. Epub 2004 Apr 20. PMID:15100224 Page seeded by OCA on Sat May 3 04:38:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1p3j"
Personal tools