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5lx3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782.== | |
| - | + | <StructureSection load='5lx3' size='340' side='right' caption='[[5lx3]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lx3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LX3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7A1:6-[4-[(6-azanylpyridin-3-yl)methylcarbamoylamino]-3-fluoranyl-phenyl]-2-(ethylamino)-~{N}-(2-piperidin-1-ylethyl)pyridine-3-carboxamide'>7A1</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lx3 OCA], [http://pdbe.org/5lx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lx3 RCSB], [http://www.ebi.ac.uk/pdbsum/5lx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lx3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Nicotinamide phosphoribosyltransferase]] | ||
[[Category: Bertrand, T]] | [[Category: Bertrand, T]] | ||
| + | [[Category: Marquette, J P]] | ||
| + | [[Category: Cancer]] | ||
| + | [[Category: Drug design]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Nampt]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:11, 25 October 2017
CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782.
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