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5lxi

From Proteopedia

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m (Protected "5lxi" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5lxi is ON HOLD
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==GABARAP-L1 ATG4B LIR Complex==
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<StructureSection load='5lxi' size='340' side='right' caption='[[5lxi]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
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Authors: Mouilleron, S., Skytte Rasmussen, M., Kumar Shrestha, B., Wirth, M., Bowitz Larsen, K., Abudu Princely, Y., Sjottem, E., Tooze, S., Lamark, T., Johansen, T., Lee, R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lxi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LXI FirstGlance]. <br>
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Description: GABARAP-L1 ATG4B LIR Complex
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxi OCA], [http://pdbe.org/5lxi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lxi RCSB], [http://www.ebi.ac.uk/pdbsum/5lxi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN]] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref> [[http://www.uniprot.org/uniprot/ATG4B_HUMAN ATG4B_HUMAN]] Cysteine protease required for autophagy, which cleaves the C-terminal part of MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Also mediates the lipid deconjugation required for target recycling.<ref>PMID:15169837</ref> <ref>PMID:19322194</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Johansen, T]]
[[Category: Lamark, T]]
[[Category: Lamark, T]]
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[[Category: Skytte Rasmussen, M]]
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[[Category: Larsen, K Bowitz]]
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[[Category: Abudu Princely, Y]]
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[[Category: Lee, R]]
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[[Category: Bowitz Larsen, K]]
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[[Category: Kumar Shrestha, B]]
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[[Category: Mouilleron, S]]
[[Category: Mouilleron, S]]
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[[Category: Wirth, M]]
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[[Category: Princely, Y Abudu]]
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[[Category: Lee, R]]
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[[Category: Rasmussen, M Skytte]]
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[[Category: Johansen, T]]
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[[Category: Shrestha, B Kumar]]
[[Category: Sjottem, E]]
[[Category: Sjottem, E]]
[[Category: Tooze, S]]
[[Category: Tooze, S]]
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[[Category: Wirth, M]]
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[[Category: Atg8]]
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[[Category: Gabarap]]
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[[Category: Lc3]]
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[[Category: Lir]]
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[[Category: Signaling protein]]

Revision as of 09:26, 10 March 2017

GABARAP-L1 ATG4B LIR Complex

5lxi, resolution 1.44Å

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