1p4n
From Proteopedia
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[[Image:1p4n.gif|left|200px]] | [[Image:1p4n.gif|left|200px]] | ||
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'''Crystal Structure of Weissella viridescens FemX:UDP-MurNAc-pentapeptide complex''' | '''Crystal Structure of Weissella viridescens FemX:UDP-MurNAc-pentapeptide complex''' | ||
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Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition., Biarrotte-Sorin S, Maillard AP, Delettre J, Sougakoff W, Arthur M, Mayer C, Structure. 2004 Feb;12(2):257-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14962386 14962386] | Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition., Biarrotte-Sorin S, Maillard AP, Delettre J, Sougakoff W, Arthur M, Mayer C, Structure. 2004 Feb;12(2):257-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14962386 14962386] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase]] | ||
[[Category: Weissella viridescens]] | [[Category: Weissella viridescens]] | ||
[[Category: Arthur, M.]] | [[Category: Arthur, M.]] | ||
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[[Category: Mayer, C.]] | [[Category: Mayer, C.]] | ||
[[Category: Sougakoff, W.]] | [[Category: Sougakoff, W.]] | ||
| - | [[Category: | + | [[Category: Femx,ligase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:40:52 2008'' | |
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Revision as of 01:40, 3 May 2008
Crystal Structure of Weissella viridescens FemX:UDP-MurNAc-pentapeptide complex
Overview
Members of the FemABX protein family are novel therapeutic targets, as they are involved in the synthesis of the bacterial cell wall. They catalyze the addition of amino acid(s) on the peptidoglycan precursor using aminoacylated tRNA as a substrate. We report here the high-resolution structure of Weissella viridescens L-alanine transferase FemX and its complex with the UDP-MurNAc-pentapeptide. This is the first structure example of a FemABX family member that does not possess a coiled-coil domain. FemX consists of two structurally equivalent domains, separated by a cleft containing the binding site of the UDP-MurNAc-pentapeptide and a long channel that traverses one of the two domains. Our structural studies bring new insights into the evolution of the FemABX and the related GNAT superfamilies, shed light on the recognition site of the aminoacylated tRNA in Fem proteins, and allowed manual docking of the acceptor end of the alanyl-tRNAAla.
About this Structure
1P4N is a Single protein structure of sequence from Weissella viridescens. Full crystallographic information is available from OCA.
Reference
Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition., Biarrotte-Sorin S, Maillard AP, Delettre J, Sougakoff W, Arthur M, Mayer C, Structure. 2004 Feb;12(2):257-67. PMID:14962386 Page seeded by OCA on Sat May 3 04:40:52 2008
